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4-aminobutirat transaminaza
Identifikatori
EC broj	2.6.1.19
CAS broj	9037-67-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

4-aminobutirat transaminaza (EC 2.6.1.19, beta-alanin-oksoglutaratna transaminaza, aminobutiratna aminotransferaza, beta-alaninska aminotransferaza, beta-alanin-oksoglutaratna aminotransferaza, gama-aminobutiratna aminotransaminaza, gama-aminobutiratna transaminaza, gama-aminobutirat-alfa-ketoglutaratna aminotransferaza, gama-aminobutirat-alfa-ketoglutaratna transaminaza, gama-aminobutirat:alfa-oksoglutarat aminotransferaza, gama-aminobutirna kiselina aminotransferaza, gama-aminobutirna kiselina transaminaza, gama-aminobutirna kiselina-alfa-ketoglutarat transaminaza, gama-aminobutirna kiselina-alfa-ketoglutarna kiselina aminotransferaza, gama-aminobutirna kiselina-2-oksoglutarat transaminaza, gama-aminobutirna transaminaza, 4-aminobutirat aminotransferaza, 4-aminobutirat-2-ketoglutarat aminotransferaza, 4-aminobutirat-2-oksoglutarat aminotransferaza, 4-aminobutirat-2-oksoglutarat transaminaza, 4-aminobutirna kiselina 2-ketoglutarinska kiselina aminotransferaza, 4-aminobutirna kiselina aminotransferaza, aminobutirat transaminaza, GABA aminotransferaza, GABA transaminaza, GABA transferaza, GABA-alfa-ketoglutarat aminotransferaza, GABA-alfa-ketoglutarat transaminaza, GABA-alfa-ketoglutaric kiselina transaminaza, GABA-alfa-oksoglutarat aminotransferaza, GABA-2-oksoglutarat aminotransferaza, GABA-2-oksoglutarat transaminaza, GABA-oksoglutarat aminotransferaza, GABA-oksoglutarat transaminaza, glutamat-sukcinski semialdehid transaminaza, GabT) je enzim sa sistematskim imenom 4-aminobutanoat:2-oksoglutarat aminotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

4-aminobutanoat + 2-oksoglutarat

\rightleftharpoons

sukcinat semialdehid + L-glutamat

Ovaj enzim je piridoksal-fosfatni protein.

Reference

↑ Scott, E.M. and Jakoby, W.B. (1959). „Soluble γ-aminobutyric-glutamic transaminase from Pseudomonas fluorescens”. J. Biol. Chem. 234: 932-936. PMID 13654294.
↑ Aurich, H. (1961). „Über die β-Alanin-α-Ketoglutarat-Transaminase aus Neurospora crassa”. Hoppe-Seyler's Z. Physiol. Chem. 326: 25-33. PMID 13863304.
↑ Schausboe, A., Wu, J.-Y. and Roberts, E. (1973). „Purification and characterization of the 4-aminobutyrate-2-ketoglutarate transaminase from mouse brain”. Biochemistry 12: 2868-2873. PMID 4719123.
↑ Bartsch, K., von Johnn-Marteville, A. and Schulz, A. (1990). „Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)”. J. Bacteriol. 172: 7035-7042. PMID 2254272.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH 4-aminobutyrate---2-oxoglutarate+transaminase

[1] Scott, E.M. and Jakoby, W.B. (1959). „Soluble γ-aminobutyric-glutamic transaminase from Pseudomonas fluorescens”. J. Biol. Chem. 234: 932-936. PMID 13654294.

[2] Aurich, H. (1961). „Über die β-Alanin-α-Ketoglutarat-Transaminase aus Neurospora crassa”. Hoppe-Seyler's Z. Physiol. Chem. 326: 25-33. PMID 13863304.

[3] Schausboe, A., Wu, J.-Y. and Roberts, E. (1973). „Purification and characterization of the 4-aminobutyrate-2-ketoglutarate transaminase from mouse brain”. Biochemistry 12: 2868-2873. PMID 4719123.

[4] Bartsch, K., von Johnn-Marteville, A. and Schulz, A. (1990). „Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)”. J. Bacteriol. 172: 7035-7042. PMID 2254272.

[1]

[2]

[3]

[4]

4-Aminobutirat transaminaza

Reference

Literatura

Vanjske veze