4-Aminobutirat—piruvat transaminaza

4-aminobutirat---piruvat transaminaza
Identifikatori
EC broj 2.6.1.96
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

4-aminobutirat---piruvat transaminaza (EC 2.6.1.96, aminobutiratna aminotransferaza, gama-aminobutiratna aminotransaminaza, gama-aminobutiratna transaminaza, gama-aminobutirno kiselinskaa aminotransferaza, gama-aminobutirna kiselina piruvatna transaminaza, gama-aminobutirna kiselina transaminaza, gama-aminobutirna transaminaza, 4-aminobutiratna aminotransferaza, 4-aminobutirna kiselina aminotransferaza, aminobutiratna transaminaza, GABA aminotransferaza, GABA transaminaza, GABA transferaza, POP2 (gen)) je enzim sa sistematskim imenom 4-aminobutanoat:piruvat aminotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) 4-aminobutanoat + piruvat sukcinat semialdehid + L-alanin
(2) 4-aminobutanoat + glioksilat sukcinat semialdehid + glicin

Za rad ovog enzima je neophodan piridoksal 5'-fosfat.

Reference

  1. ↑ Van Cauwenberghe, O.R. and Shelp, B.J. (1999). „Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum”. Phytochemistry 52: 575-581. 
  2. ↑ Palanivelu, R., Brass, L., Edlund, A.F. and Preuss, D. (2003). „Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels”. Cell 114: 47-59. PMID 12859897. 
  3. ↑ Clark, S.M., Di Leo, R., Dhanoa, P.K., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis γ-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate”. J. Exp. Bot. 60: 1743-1757. PMID 19264755. 
  4. ↑ Clark, S.M., Di Leo, R., Van Cauwenberghe, O.R., Mullen, R.T. and Shelp, B.J. (2009). „Subcellular localization and expression of multiple tomato γ-aminobutyrate transaminases that utilize both pyruvate and glyoxylate”. J. Exp. Bot. 60: 3255-3267. PMID 19470656. 

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