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4,4'-diapofitoen desaturaza
Identifikatori
EC broj	1.3.8.2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

4,4'-diapofitoen desaturaza (EC 1.3.8.2, dehidroskvalenska desaturaza, CrtN, 4,4'-diapofitoen:FAD oksidoreduktaza) je enzim sa sistematskim imenom 15-cis-4,4'-diapofitoen:FAD oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

15-cis-4,4'-diapofitoen + 4 FAD

\rightleftharpoons

sve--trans-4,4'-diapolikopen + 4 FADH₂ (sveukupna reakcija)

(1a) 15-cis-4,4'-diapofitoen + FAD

\rightleftharpoons

sve-trans-4,4'-diapofitofluen + FADH₂

(1b) sve-trans-4,4'-diapofitofluen + FAD

\rightleftharpoons

sve-trans-4,4'-diapo-zeta-karoten + FADH₂

(1c) sve-trans-4,4'-diapo-zeta-karoten + FAD

\rightleftharpoons

sve-trans-4,4'-diaponeurosporen + FADH₂

(1d) sve-trans-4,4'-diaponeurosporen + FAD

\rightleftharpoons

sve-trans-4,4'-diapolikopen + FADH₂

Ovaj enzim je tipičan za Staphylococcus aureus i neke druge bakterije kao što je Heliobacillus sp. On je odgovoran za četiri sukcesivne dehidrogenacije.

Reference

↑ Wieland, B., Feil, C., Gloria-Maercker, E., Thumm, G., Lechner, M., Bravo, J.M., Poralla, K. and Gotz, F. (1994). „Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4′-diaponeurosporene of Staphylococcus aureus”. J. Bacteriol. 176: 7719-7726. PMID 8002598.
↑ Raisig, A. and Sandmann, G. (1999). „4,4′-diapophytoene desaturase: catalytic properties of an enzyme from the C₃₀ carotenoid pathway of Staphylococcus aureus”. J. Bacteriol. 181: 6184-6187. PMID 10498735.
↑ Raisig, A. and Sandmann, G. (2001). „Functional properties of diapophytoene and related desaturases of C₃₀ to C₄₀ carotenoid biosynthetic pathways”. Biochim. Biophys. Acta 1533: 164-170. PMID 11566453.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH 4,4'-diapophytoene+desaturase

[1] Wieland, B., Feil, C., Gloria-Maercker, E., Thumm, G., Lechner, M., Bravo, J.M., Poralla, K. and Gotz, F. (1994). „Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4′-diaponeurosporene of Staphylococcus aureus”. J. Bacteriol. 176: 7719-7726. PMID 8002598.

[2] Raisig, A. and Sandmann, G. (1999). „4,4′-diapophytoene desaturase: catalytic properties of an enzyme from the C₃₀ carotenoid pathway of Staphylococcus aureus”. J. Bacteriol. 181: 6184-6187. PMID 10498735.

[3] Raisig, A. and Sandmann, G. (2001). „Functional properties of diapophytoene and related desaturases of C₃₀ to C₄₀ carotenoid biosynthetic pathways”. Biochim. Biophys. Acta 1533: 164-170. PMID 11566453.

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