3a(or 20b)-hidroksisteroid dehidrogenaza

3a(or 20b)-hidroksisteroid dehidrogenaza (EC 1.1.1.53, kortizon reduktaza, (R)-20-hidroksisteroid dehidrogenaza, dehidrogenaza, 20beta-hidroksi steroid, Delta4-3-ketosteroid hidrogenaza, 20beta-hidroksisteroid dehidrogenaza, 3alfa,20beta-hidroksisteroid:NAD+-oksidoreduktaza, NADH-20beta-hidroksisteroid dehidrogenaza, 20beta-HSD) je enzim sa sistematskim imenom 3alfa(or 20beta)-hidroksisteroid:NAD⁺ oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

androstaN-3alfa,17beta-diol + NAD⁺

\rightleftharpoons

17beta-hidroksiandrostaN-3-on + NADH + H⁺

3alfa-hidroksi grupa ili 20beta-hidroksi grupa pregnana i androstanskih steroida mogu da deluju kao donori.

Reference

↑ Edwards, C.A.F. and Orr, J.C. (1978). „Comparison of the 3α-and 20β-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans”. Biochemistry 17: 4370-4376. PMID 718844.
↑ Hübener, H.J. and Sahrholz, F.G. (1960). „20β-hydroxy-steroid-dehydrogenase. II. Darstellung und Kristallisation”. Biochem. Z. 333: 95-105. PMID 14403761.
↑ Hübener, H.J., Sahrholz, F.G., Schmidt-Thomé, J., Nesemann, G. and Junk, R. (1959). „20β-Hydroxy-Steroid-Dehydrogenase, ein neues kristallines Enzym”. Biochim. Biophys. Acta 35: 270-272. PMID 14403760.
↑ Lynn, W.S. and Brown, R.H. (1958). „The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015-1030. PMID 13549484.
↑ Strickler, R.C., Covey, D.F. and Tobias, B. (1980). „Study of 3α, 20 β-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site”. Biochemistry 19: 4950-4954. PMID 6936053.
↑ Sweet, F. and Samant, B.S. (1980). „Bifunctional enzyme activity at the same active site: study of 3α and 20β activity by affinity alkylation of 3α, 20β-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids”. Biochemistry 19: 978-986. PMID 6928375.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH 3alpha(or+20beta)-hydroxysteroid+dehydrogenase

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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