3-Hidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion monooksigenaza

3-Hidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion monooksigenaza
Identifikatori
EC broj 1.14.14.12
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

3-Hidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion monooksigenaza (EC 1.14.14.12, HsaA) je enzim sa sistematskim imenom 3-hidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion,FMNH2:kiseonik oksidoreduktaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

3-hidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion + FMNH2 + O2 3,4-dihidroksi-9,10-sekoandrosta-1,3,5(10)-trien-9,17-dion + FMN + H2O

Ovaj bakterijski enzim učestvuje u degradaciji nekoliko steroida, uključujući holesterol i testosteron. On koristi FADH ili FMNH2 kao flavinski kofaktor.

Reference

  1. ↑ Dresen, C., Lin, L.Y., D'Angelo, I., Tocheva, E.I., Strynadka, N. and Eltis, L.D. (2010). „A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism”. J. Biol. Chem. 285: 22264-22275. PMID 20448045. 

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