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(Skp1-protein)-hidroksiprolin N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.229
CAS broj	256531-81-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

(Skp1-protein)-hidroksiprolin N-acetilglukozaminiltransferaza (EC 2.4.1.229, Skp1-HyPro GlcNAc-transferaza, UDP-N-acetilglukozamin (GlcNAc):hidroksiprolin polipeptid GlcNAc-transferaza, UDP-GlcNAc:Skp1-hidroksiprolin GlcNAc-transferaza, UDP-GlcNAc:hidroksiprolin polipeptid GlcNAc-transferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:(Skp1-protein)-hidroksiprolin N-acetil-D-glukozaminil-transferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetilglukozamin + [Skp1-protein]-hidroksiprolin

\rightleftharpoons

UDP + [Skp1-protein]-O-(N-acetil-D-glukozaminil)hidroksiprolin

Za dejstvo ovog enzima je neophodan ditiotreitol i divalentni katjon.

Reference

↑ van der Wel, H., Morris, H.R., Panico, M., Paxton, T., Dell, A., Kaplan, L. and West, C.M. (2002). „Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of Dictyostelium”. J. Biol. Chem. 277: 46328-46337. PMID 12244115.
↑ Teng-umnuay, P., van der Wel, H. and West, C.M. (1999). „Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium”. J. Biol. Chem. 274: 36392-36402. PMID 10593934.
↑ West, C.M., van der Wel, H. and Gaucher, E.A. (2002). „Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins”. Glycobiology 12: 17-17. PMID 11886837.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH (Skp1-protein)-hydroxyproline+N-acetylglucosaminyltransferase

[1] van der Wel, H., Morris, H.R., Panico, M., Paxton, T., Dell, A., Kaplan, L. and West, C.M. (2002). „Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of Dictyostelium”. J. Biol. Chem. 277: 46328-46337. PMID 12244115.

[2] Teng-umnuay, P., van der Wel, H. and West, C.M. (1999). „Identification of a UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase in the cytoplasm of Dictyostelium”. J. Biol. Chem. 274: 36392-36402. PMID 10593934.

[3] West, C.M., van der Wel, H. and Gaucher, E.A. (2002). „Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins”. Glycobiology 12: 17-17. PMID 11886837.

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