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(S)-3-hidroksikiselina ester dehidrogenaza
Identifikatori
EC broj	1.1.1.280
CAS broj	114705-03-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

(S)-3-hidroksikiselina ester dehidrogenaza (EC 1.1.1.280, 3-okso ester (S)-reduktaza) je enzim sa sistematskim imenom etil-(S)-3-hidroksiheksanoat:NADP⁺ 3-oksidoreduktaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

etil (S)-3-hidroksiheksanoat + NADP⁺

\rightleftharpoons

etil 3-oksoheksanoat + NADPH + H⁺

Dehidrogenaza estra (S}0)-3-hidroksikiseline takođe deluje na 4-okso- i 5-okso-masne kiseline I njihove estre, cf. EC 1.1.1.279, (R)-3-hidroksikiselina-ester dehidrogenaza.

Reference

↑ Heidlas, J., Engel, K.-H. and Tressl, R. (1988). „Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast”. Eur. J. Biochem. 172: 633-639. PMID 3280313.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH (S)-3-hydroxyacid-ester+dehydrogenase

[1] Heidlas, J., Engel, K.-H. and Tressl, R. (1988). „Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast”. Eur. J. Biochem. 172: 633-639. PMID 3280313.

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