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(Butirosin acil-nosilac protein)—L-glutamat ligaza
Identifikatori
EC broj	6.2.1.39
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

(Butirosin acil-nosilac protein)—L-glutamat ligaza (EC 6.2.1.39, (BtrI acil-nosilac protein)—L-glutamat ligaza, BtrJ) je enzim sa sistematskim imenom (BtrI acil-nosilac protein):L-glutamat ligaza (formira ADP).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) ATP + L-glutamat + BtrI acil-nosilac protein

\rightleftharpoons

ADP + fosfat + L-glutamil-[BtrI acil-nosilac protein]

(2) ATP + L-glutamat + 4-amino butanoil-[BtrI acil-nosilac protein]

\rightleftharpoons

ADP + fosfat + 4-(gama-L-glutamilamino)butanoil-[BtrI acil-nosilac protein]

Ovaj enzim katalizuje dva koraka u biosintezi bočnog lanca aminoglikozidnih antibiotika iz butirozinske familije.

Reference

↑ Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. (2005). „Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway”. Chem. Biol. 12: 665-675. PMID 15975512.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH (butirosin+acyl-carrier+protein)-L-glutamate+ligase

[1] Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. (2005). „Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway”. Chem. Biol. 12: 665-675. PMID 15975512.

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