(Acetil-KoA karboksilaza) kinaza

(acetil-KoA karboksilaza) kinaza
Identifikatori
EC broj 2.7.11.27
CAS broj 77000-06-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

(acetil-KoA karboksilaza) kinaza (EC 2.7.11.27, acetil koenzim A karboksilaza kinaza (fosforilacija), acetil-KoA karboksilaza vezana kinaza, acetil-KoA karboksilazna kinaza, acetil-KoA karboksilazna kinaza (cAMP-nezavisna), acetil-KoA karboksilazna kinaza 2, acetil-KoA karboksilazna kinaza-2, acetil-KoA karboksilazna kinaza-3 (AMP-activated), acetil-koenzim A karboksilazna kinaza, ACK2, ACK3, AMPK, I-peptid kinaza, STK5) je enzim sa sistematskim imenom ATP:(acetil-KoA karboksilaza) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [acetil-KoA karboksilaza] ADP + [acetil-KoA karboksilaza] fosfat

Ovaj enzim fosforiliše i inaktivira EC 6.4.1.2, acetil-KoA karboksilazu.

Reference

  1. ↑ Jamil, H. and Madsen, N.B. (1987). „Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations”. J. Biol. Chem. 262: 630-637. PMID 2879833. 
  2. ↑ Lent, B. and Kim, K.H. (1982). „Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase”. J. Biol. Chem. 257: 1897-1901. PMID 6120170. 
  3. ↑ Munday, M.R. and Hardie, D.G. (1984). „Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity”. Eur. J. Biochem. 141: 617-627. PMID 6146523. 
  4. ↑ Mohamed, A.H., Huang, W.Y., Huang, W., Venkatachalam, K.V. and Wakil, S.J. (1994). „Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver”. J. Biol. Chem. 269: 6859-6865. PMID 7907095. 
  5. ↑ Heesom, K.J., Moule, S.K. and Denton, R.M. (1998). „Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase”. FEBS Lett. 422: 43-46. PMID 9475166. 

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