Альфа-гранулы тромбоцитов

Альфа-гранулы тромбоцитов — особые внутриклеточные гранулы, в которых тромбоциты хранят несколько факторов роста (инсулиноподобный фактор роста 1, тромбоцитарный фактор роста, TGFβ), тромбоцитарный фактор 4 (гепарин-связывающий хемокин) и другие белки системы тромбообразования (тромбоспондин, фибронектин и фактор фон Виллебранда). Кроме этого, мембрана гранул содержит P-селектин и CD63. Недостаточность альфа-гранул приводит к т.н. синдрому серых тромбоцитов.

См. также

Ссылки

  • Harrison P., Cramer E.M. Platelet alpha-granules (англ.) // Blood Rev.[англ.] : journal. — 1993. — March (vol. 7, no. 1). — P. 52—62. — PMID 8467233.

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