Этирацетам

Этирацетам
Изображение химической структуры Изображение молекулярной модели
Общие
Хим. формула C8H14N2O2
Классификация
Рег. номер CAS 33996-58-6
PubChem 59708
Рег. номер EINECS 642-997-0
SMILES
 
InChI
 
ChEBI 176724
ChemSpider 53863
Приведены данные для стандартных условий (25 °C, 100 кПа), если не указано иное.
Логотип Викисклада Медиафайлы на Викискладе

Этирацетам [(RS)-α-этил-(2-оксо-1-пирролидинил)ацетамид] получен C. Giurgea с соавторами в 1984 году (UCB Pharma, Бельгия)[1], а его (S)-изомер — в 1985 году (UCB Pharma, Бельгия)[2][3]. Этирацетам проявляет ноотропную активность[4]. (S)-Энантиомер этирацетама — леветирацетам (Keppra®) — применяется в медицинской практике в качестве антиэпилептического препарата с 1999 года в США и с 2003 года в РФ[5].

Примечания

  1. ↑ Пат.: EP 0165919. (R)-L-Ethyl-2-oxo-1-pyrrolidine acetamide / Gobert J., Giurgea C., Geerts J.P., Bodson G. 1984. // C. A. 1986. Vol. 105. 97305a.
  2. ↑ Gouliaev A., Monster J., Vedso M., Senning A. Synthetic and analytical aspects of the chemistry of piracetam type substituted pyrrolidines. A review // Organic preparations and procedures int. 1995. Vol. 27. № 3. P. 273—303.
  3. ↑ Пат.: US 4696943 A1. (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide / Gobert J., Geerts J.-P., Bodson G. 1985. [EP 162036.(S)-alpha-ethyl-2-oxo- 1-pyrrolidineacetamide / Gobert J., Geerts J.-P., Bodson G. 1985. // C. A. 1986. Vol. 105. 018467.
  4. ↑ Берестовицкая В. М., Тюренков И. Н., Васильева О. С., Перфилова В. Н., Остроглядов Е. С., Багметова В. В. Рацетамы: методы синтеза и биологическая активность. Монография. — СПб.: Астерион, 2016. — 287 с.
  5. ↑ Власов П. Н. Опыт клинического применения ламотриджина, топирамата и леветирацетама у взрослых за рубежом и в России // Фарматека. 2004. № 19-20. С. 7.

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