Йодоцианопиндолол

Iodocyanopindolol
Изображение химической структуры
Химическое соединение
ИЮПАК (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
Брутто-формула C16H20IN3O2
Молярная масса 413.25 г/моль
CAS 85124-14-7
PubChem 187238
Состав
Логотип Викисклада Медиафайлы на Викискладе

Йодоцианопиндолол (МНН) — это лекарство, структурно связанное с пиндололом и цианопиндололом, и являющееся одновременно β1-селективным адреноблокатором и антагонистом 5-HT1A-рецепторов.[1] Его меченый короткоживущим радиоактивным изотопом йода вариант 125I-йодоцианопиндолол широко используется в ауторадиографическом изучении распределения β1-адренорецепторов в организме.[2]

Примечания

  1. ↑ Adham N1, Tamm JA, Salon JA, Vaysse PJ, Weinshank RL, Branchek TA. A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists. (англ.) // Neuropharmacology. — Mar-Apr 1994. — Vol. 33, iss. 33(3—4), no. 3—4. — P. 387—391. — PMID 7984276. Архивировано 24 марта 2015 года.
  2. ↑ Brodde O.E., Karad K., Zerkowski H.R., Rohm N., Reidemeister J.C. Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding (англ.) // Circulation Research[англ.] : journal. — 1983. — Vol. 53, no. 6. — P. 752—758. — doi:10.1161/01.res.53.6.752. — PMID 6139182.

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