Piruvato desidrogenase

piruvato desidrogenase (lipoamida) alfa 1
Indicadores
Símbolo PDHA1
Símbolos alt. PDHA
HUGO 8806
Entrez 5160
OMIM 300502
RefSeq NM_000284
UniProt P08559
Outros dados
Número EC 1.2.4.1
Locus Cr. X p22.1
piruvato desidrogenase (lipoamida) alfa 2
Indicadores
Símbolos alt. PDHAL
HUGO 8807
Entrez 5161
OMIM 179061
RefSeq NM_005390
UniProt P29803
Outros dados
Número EC 1.2.4.1
Locus Cr. 4 q22-q23
piruvato desidrogenase (lipoamida) beta
Indicadores
Símbolo PDHB
HUGO 8808
Entrez 5162
OMIM 179060
RefSeq NM_000925
UniProt P11177
Outros dados
Número EC 1.2.4.1
Locus Cr. 3 p21.1-14.2

A piruvato desidrogenase é o primeiro componente do complexo enzimático piruvato desidrogenase. EC 1.2.4.1.

Função

E1 executa a primeira de duas reacções no complexo. Elas são:

Regulação

Fosforilação de E1 pela piruvato desidrogenase quinase inativa E1 e subsequentemente todo o complexo.

Esta ação é revertida pela alta relação Insulina/Glucagon, que têm como consequência o aumento da transcrição da piruvato desidrogenase fosfatase, e repressão do gene da piruvato desidrogenase quinase. Tal mecanismo resulta em alta produção de Acetil-CoA.

Genes

E1 é uma proteína multimérica:

  • As E1 de mamíferos, incluindo a E1 humana, são tetraméricas, compostas de duas subunidades α e duas subunidades β.[1]
  • algumas E1 bacterianas, incluindo a E1 de Escherichia coli, são compostas por duas subunidades similares, cada uma delas com uma massa molecular tão grande quanto a soma das subunidades α e β.[2]

Outras formas

Em bactérias, existe uma forma de piruvato desidrogenase, também denominada piruvato oxidase (EC 1.2.2.2). Esta enzima liga a oxidação do piruvato em acetato e dióxido de carbono à redução de ferrocitrocromo. Em E. coli esta enzima é codificada pelo gene pox B e a proteína possui um cofactor flavínico.[3] A enzima aumenta a eficiência do crescimento de E. coli sob condições aeróbica.[4]

Referências

  1. ↑ Ciszak E, Korotchkina L, Dominiak P, Sidhu S, Patel M (2003). «Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase». J Biol Chem. 278 (23): 21240-6. PMID 12651851 
  2. ↑ Arjunan P, Nemeria N, Brunskill A, Chandrasekhar K, Sax M, Yan Y, Jordan F, Guest JR, Furey W. (2002). «Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution». Biochemistry. 41 (16): 5213-21. PMID 11955070 
  3. ↑ Recny MA, Hager LP (1982). «Reconstitution of native Escherichia coli pyruvate oxidase from apoenzyme monomers and FAD». J. Biol. Chem. 257 (21): 12878-86. PMID 6752142 
  4. ↑ Abdel-Hamid AM, Attwood MM, Guest JR (2001). «Pyruvate oxidase contributes to the aerobic growth efficiency of Escherichia coli». Microbiology (Reading, Engl.). 147 (Pt 6): 1483-98. PMID 11390679 

Read other articles:

Xaronval

Peta wilayah Xaronval. Xaronval merupakan sebuah komune di departemen Vosges yang terletak pada sebelah timur laut Prancis. Lihat pula Komune di departemen Vosges Referensi INSEE lbsKomune di departemen Vosges Les Ableuvenettes Ahéville Aingeville Ainvelle Allarmont Ambacourt Ameuvelle Anglemont Anould Aouze Arches Archettes Aroffe Arrentès-de-Corcieux Attignéville Attigny Aulnois Aumontzey Autigny-la-Tour Autreville Autrey Auzainvilliers Avillers Avrainville Avranville Aydoilles Badménil...

 

 

Praseodimium

59PrPraseodimiumPotongan praseodimium berukuran 5 mm Garis spektrum praseodimiumSifat umumNama, lambangpraseodimium, PrPengucapan/praséodimium/[1] Penampilanputih keabu-abuanPraseodimium dalam tabel periodik 59Pr Hidrogen Helium Lithium Berilium Boron Karbon Nitrogen Oksigen Fluor Neon Natrium Magnesium Aluminium Silikon Fosfor Sulfur Clor Argon Potasium Kalsium Skandium Titanium Vanadium Chromium Mangan Besi Cobalt Nikel Tembaga Seng Gallium Germanium Arsen Selen Bromin Kripton...

 

 

Charles Le Moyne (pemeran)

Charles Le MoyneHarry Carey dan Charles Le Moyne dalam Sundown Slim (1920)LahirCarl Jonathan Lemon(1880-06-27)27 Juni 1880Marshall, Illinois, Amerika SerikatMeninggal13 September 1956(1956-09-13) (umur 76)Hollywood, California, Amerika SerikatPekerjaanPemeranTahun aktif1915-1937 Charles Le Moyne (27 Juni 1880 – 13 September 1956) adalah seorang pemeran film Amerika Serikat dari era film bisu. Ia tampil dalam 73 film antara 1915 dan 1937. Filmografi pilihan The Princ...

Bandul

Bandul yang mengalami osilasi ayunan. Bandul yang mempunyai arah vektor kecepatan (v) dan percepatan (a) Bandul adalah benda yang terikat pada sebuah tali dan dapat berayun secara bebas dan periodik yang menjadi dasar kerja dari sebuah jam dinding kuno yang mempunyai ayunan. Galileo Galilei memang dikenal sebagai ilmuwan yang berhasil menemukan pendulum (bandul/ayunan) yang berfungsi membantu penelitian tentang benda luar angkasa. Namun pencetus temuan pendulum itu sejatinya adalah seorang il...

 

 

Piala Raja Spanyol 1914

Piala Raja Spanyol 1914Negara SpanyolJumlah peserta4Juara bertahanRacing de Irún (RFEF)Barcelona (UECF)JuaraAthletic Bilbao(gelar ke-5)Tempat keduaEspanyaJumlah pertandingan5Jumlah gol23 (4.6 per pertandingan)← 1913 1915 → Piala Raja Spanyol 1914 adalah edisi ke-12 dari penyelenggaraan Piala Raja Spanyol, turnamen sepak bola di Spanyol dengan sistem piala. Edisi ini dimenangkan oleh Athletic Bilbao setelah mengalahkan Espanya pada pertandingan final dengan skor 2–1. Final Artikel ...

 

 

Constitutional monarchy

Form of government Part of the Politics seriesMonarchy Central concepts MonarchMonarchismDivine right of kingsMandate of HeavenRoyal prerogative Types Abdication system Absolute Chinese Legalist Composite Constitutional Crowned republic Diarchy Dual Elective Emirate Ethnarch Federal Hereditary Khanate Non-sovereign Pentarchy Personal union Popular Principality Regency Coregency Self-proclaimed Signoria Tetrarch Triarchy Universal Philosophy Philosophers Aquinas Dante Bodin Bellarmine Filmer H...

Intelligence (American TV series)

American cyber-themed action-adventure television series IntelligenceGenre Action/Adventure Drama Espionage Science fiction Created byMichael SeitzmanDeveloped byMichael SeitzmanTripp VinsonStarring Josh Holloway Meghan Ory Michael Rady John Billingsley P. J. Byrne Marg Helgenberger Theme music composerClinton ShorterComposerClinton ShorterCountry of originUnited StatesOriginal languageEnglishNo. of seasons1No. of episodes13ProductionExecutive producers Michael Seitzman Tripp Vinson Barry Sch...

 

 

Unsur periode 7

Periode 7 dalam tabel periodik Hidrogen Helium Lithium Berilium Boron Karbon Nitrogen Oksigen Fluor Neon Natrium Magnesium Aluminium Silikon Fosfor Sulfur Clor Argon Potasium Kalsium Skandium Titanium Vanadium Chromium Mangan Besi Cobalt Nikel Tembaga Seng Gallium Germanium Arsen Selen Bromin Kripton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum Technetium Ruthenium Rhodium Palladium Silver Cadmium Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodym...

 

 

Basilika Santa Ida, Lippetal

Basilika Santa IdaBasilika Minor Santa IdaJerman: Wallfahrtskirche St. Idacode: de is deprecated Basilika Santa IdaLokasiLippetalNegara JermanDenominasiGereja Katolik RomaArsitekturStatusBasilika minorStatus fungsionalAktifAdministrasiKeuskupanKeuskupan Münster Basilika Santa Ida (Jerman: Wallfahrtskirche St. Idacode: de is deprecated ) adalah sebuah gereja basilika minor Katolik yang terletak di Lippetal, Jerman. Basilika ini ditetapkan statusnya pada 2011 dan didedikasikan kepada Sant...

Okapi

Okapi Okapi di Disney's Animal Kingdom Status konservasi Hampir Terancam Klasifikasi ilmiah Kerajaan: Animalia Filum: Chordata Kelas: Mammalia Superordo: Cetartiodactyla Ordo: Artiodactyla Famili: Giraffidae Subfamili: Okapiinae Genus: OkapiaLankester, 1901 Spesies: O. johnstoni Nama binomial Okapia johnstoni(P.L. Sclater, 1901) Induk Okapi dengan Anaknya Okapi (Okapia johnstoni) adalah mamalia dari Hutan Hujan Ituri di Afrika Tengah. Walaupun hewan ini memiliki kesamaan belang kulit de...

 

 

Anna Jean Ayres

Anna Jean AyresLahir(1920-01-18)18 Januari 1920Visalia, CaliforniaMeninggal16 Desember 1989(1989-12-16) (umur 69)Los AngelesDikenal atasPsikolog perkembanganKarya terkenalIntegrasi Sensorik dan Gangguan Belajar (1972) Anna Jean Ayres (18 Januari 1920 – 16 Desember 1989) adalah ahli terapi okupasi dari tahun 1946 - 1955 pada beberapa pusat rehabilitasi di California. Dia mengajar dan melakukan riset pada bagian terapi okupasi[1] di Universitas Southern California....

 

 

KDKL (FM)

Radio station in Okemah, OklahomaKDKLOkemah, OklahomaBroadcast areaCentral Oklahoma, including portions of Tulsa and Oklahoma City metropolitan areas.Frequency103.7 MHzBrandingK-LoveProgrammingFormatContemporary ChristianOwnershipOwnerEducational Media FoundationHistoryFormer call signsKESC (2001–2007)KOCD (2007–2011)KYLK (2011–2023)[1]Technical informationFacility ID83209ClassC1ERP72,000 wattsHAAT282 meters (925 feet)Transmitter coordinates35°15′47″N 96°22′43″W...

The Lego Movie Videogame

2014 video game 2014 video gameThe Lego Movie VideogameCover art for The Lego Movie VideogameDeveloper(s)TT FusionPublisher(s)Warner Bros. Interactive EntertainmentFeral Interactive (OS X)Director(s)Jon BurtonProgrammer(s)Phil OwenTom MatthewsArtist(s)Paul JonesComposer(s)Mark MothersbaughMutato MuzikaSuperman (1978) music composed by John WilliamsWonder Woman (1975 TV series) composed by Charles FoxSeriesThe Lego MoviePlatform(s)iOSMicrosoft WindowsNintendo 3DSOS XPlayStation 3PlayStation 4P...

 

 

大字 (数字)

この項目には、一部のコンピュータや閲覧ソフトで表示できない文字が含まれています（詳細）。 数字の大字（だいじ）は、漢数字の一種。通常用いる単純な字形の漢数字（小字）の代わりに同じ音の別の漢字を用いるものである。 概要 壱万円日本銀行券（「壱」が大字） 弐千円日本銀行券（「弐」が大字） 漢数字には「一」「二」「三」と続く小字と、「壱」「�...

 

 

Cradlesong Tour

2009–10 concert tour by Rob Thomas Cradlesong TourTour by Rob ThomasPromotional poster for the tourAssociated albumCradlesongSomeday EPStart dateSeptember 18, 2009 (2009-09-18)End dateAugust 28, 2010 (2010-08-28)Legs3No. of shows59 in North America11 in Australia70 totalRob Thomas concert chronology Something to Be Tour(2005–06) Cradlesong Tour(2009–10) The Great Unknown Tour(2015) The Cradlesong Tour (stylized cradlesong tour) was the second solo concert t...

Taiwanese opera

Form of traditional drama originating in Taiwan A Taiwanese opera group performing during the Dragon Boat Festival A Taiwanese opera group pan-sian performing Taiwanese opera (Chinese: 歌仔戲; pinyin: gēzǎixì; Pe̍h-ōe-jī: koa-á-hì; lit. 'Song Drama') commonly known as Ke-Tse opera or Hokkien opera, is a form of traditional drama originating in Taiwan.[1] Taiwanese opera uses a stylised combination of both the literary and colloquial registers of Taiwanes...

 

 

Ippolito de' Medici

Italian Catholic cardinal (1511–1535) Ippolito de' MediciPortrait by Cristofano dell'Altissimo, c. 1605Lord of FlorenceReign19 November 1523 – 16 May 1527PredecessorGiulio de' MediciSuccessorAlessandro de' Medici Born(1511-03-00)March 1511Florence, Republic of FlorenceDied10 August 1535(1535-08-10) (aged 24)Itri, Kingdom of NaplesNoble familyMediciFatherGiuliano de' MediciMotherPacifica Brandano Ippolito de' Medici (March 1511[1] – 10 August 1535) was the only son...

 

 

Political views of American academics

The political views of American academics began to receive attention in the 1930s, and investigation into faculty political views expanded rapidly after the rise of McCarthyism. Demographic surveys of faculty that began in the 1950s and continue to the present have found higher percentages of liberals than of conservatives, particularly among those who work in the humanities and social sciences. Researchers and pundits disagree about survey methodology and about the interpretations of the fi...

Nemzeti Bajnokság I/A (women's basketball)

Hungarian sports league Hungarian national championship for women'sCurrent season, competition or edition: 2021–22 Nemzeti Bajnokság I/A (women's basketball)SportBasketballFounded1933First season1933No. of teams12Country Hungary HungaryContinentFIBA Europe (Europe)Most recentchampion(s)Sopron Basket (16th title)Most titlesBSE Budapest (21 titles)[1]Official websitekosarsport.hu The Hungarian national championship for women's (English: National Championship I/A, commonly abbrev...

 

 

Major League Baseball on ABC

American TV series or program Major League Baseball on ABCAlso known as Monday Night Baseball Sunday Afternoon Baseball Thursday Night Baseball Baseball Night in America ESPN Major League Baseball GenreMajor League Baseball game telecastsDeveloped byABC SportsDirected bySteve Danz[1]Chet ForteKen FoutsCraig Janoff[2]Larry KammStarringMajor League Baseball on ABC broadcastersTheme music composerCharles FoxRobert Israel[3]Lillian Scheinert[4][5]Kurt Best...