Melitraceno

O melitraceno é um antidepressivo tricíclico, comercializado na Europa e Japão pela Lundbeck e Takeda, respectivamente, para o tratamento da depressão e ansiedade.[1][2][3][4]

Para além de ser vendida em preparação simples de droga única, está também disponível como combinação contendo melitraceno e flupentixol.[5][6][7][8]

A farmacologia do melitraceno ainda não foi investigada de maneira apropriada e é largamente desconhecida, mas pensa-se de atue de maneira similar ao outros antidepressivos tricíclicos. De fato, há relatos de que o melitraceno tem efeitos e eficácia semelhantes à imipramina e à amitriptilina, mas com tolerância melhorada e um menor intervalo de tempo até ser observada a sua ação.[9][10]

Ver também

Referências

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0 
  2. ↑ Hall, Chapman and; Chemical Abstracts Service, American Chemical Society; Rhodes, P. H (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8 
  3. ↑ O'Neil, Maryadele J. (2001). The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories. ISBN 0-911910-13-1 
  4. ↑ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4 
  5. ↑ Muller, Niels F; Dessing, Rudolf P; Pharmacy, European Society of Clinical (1998). European Drug Index, 4th Edition. Boca Raton: CRC Press. ISBN 3-7692-2114-1 
  6. ↑ Van Moffaert M, Dierick M, De Meulemeester F, Vereecken A (1983). «Treatment of depressive anxiety states associated with psychosomatic symptoms. A double-blind multicentre clinical study: mianserin versus melitracen-flupentixol». Acta Psychiatrica Belgica. 83 (5): 525–39. PMID 6670581 
  7. ↑ Bin Yaacob H (1985). «Flupenthixol and Melitracen in the management of trigeminal neuralgia». Dental Journal of Malaysia. 8 (2): 37–8. PMID 3917005 
  8. ↑ Hashash JG, Abdul-Baki H, Azar C; et al. (2008). «Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia». Alimentary Pharmacology & Therapeutics. 27 (11): 1148–55. PMID 18331614. doi:10.1111/j.1365-2036.2008.03677.x [ligação inativa]
  9. ↑ Aronson, Jeffrey Kenneth (2008). Meyler's Side Effects of Psychiatric Drugs (Meylers Side Effects). Amsterdam: Elsevier Science. ISBN 0-444-53266-8 
  10. ↑ Author Unknown (1970). Ann Reports Medicinal Chem V5 (v. 5). Boston: Academic Press. ISBN 0-12-040505-9 

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