Expressão ectópica

Expressão ectópicaé uma expressão anormal do gene em um tipo de célula, tipo de tecido ou estágio de desenvolvimento no qual o gene geralmente não é expresso.[1][2]

Pode ser causada por uma doença ou ser artificialmente induzida com vista a determinar a função do gene. Dessa forma pode ser classificado uma expressão inapropriada de um gene podendo ter importantes consequências, conforme surpreendentemente revelado com o gene FGF4 em cães[3]

Referências

  1. ↑ Cox, Timothy C.; Camci, Esra D.; Vora, Siddharth; Luquetti, Daniela V.; Turner, Eric E. (2014). «The genetics of auricular development and malformation: New findings in model systems driving future directions for microtia research». European Journal of Medical Genetics. 57 (8): 394–401. PMC 4143470Acessível livremente. PMID 24880027. doi:10.1016/j.ejmg.2014.05.003 
  2. ↑ Merriam, John R. (2001). «Genes with ectopic expression phenotypes are common, not rare» (PDF). Molecular Cell and Developmental Biology. 84: 130–132 
  3. ↑ Tom Strachan, Andrew Read Artmed Editora, 1 de out de 2016 - 808 páginas

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