Dermaseptina

Dermaseptina
Indicadores
TCDB 1.C.52
Família OPM 309
Proteína OPM 2dd6

Dermaseptina é uma família de peptídeos isolados da pele de anfíbios da subfamília Phyllomedusinae.[1] Os peptídeos antimicrobianos já foram isolados das espécies: Phyllomedusa bicolor, Phyllomedusa sauvagii, Phyllomedusa distincta, Phyllomedusa tarsius, Phyllomedusa hypochondrialis, Phyllomedusa oreades, Phyllomedusa trinitatis, Pachymedusa dacnicolor, Agalychnis annae, Agalychnis callidryas, Agalychnis litodryas e Hylomantis lemur.[2]

As sequências das dermaseptinas variam muito, mas devido a presença de resíduos de lisina todas são catiônicas e a maioria têm o potencial de formar hélices anfipáticas na água ou quando integradas com a bicamada lipídica da membrana bacteriana.[3] Uma separação clara de dois lóbulos de potencial eletrostático intramolecular positivo e negativo é considerado o fator importante na atividade citotóxica. As dermaseptinas são tipicamente constituídas de 27-34 resíduos de aminoácidos em comprimento e foram os primeiros peptídeos de vertebrados que demonstraram ter efeito letal em fungos filamentosos implicados em severas infecções oportunistas associadas com a síndrome da imunodeficiência e terapias com drogas imunossupressoras.[4]

Referências

  1. ↑ Amiche, M.; Seon, A.A.; Pierre, T.N.; Nicolas, P. (1999). «The dermaseptin precursors: a protein family with a common preproregion and a variable C-terminal antimicrobial domain». FEBS Letters. 456 (3): 352–356 
  2. ↑ Nicolas, P.; Em Amri, C. (2009). «The dermaseptin superfamily: A gene-based combinatorial library of antimicrobial peptides». Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788 (8): 1537-1550. doi:10.1016/j.bbamem.2008.09.006 
  3. ↑ Hancock, R.E.W.; Falla, T.; Brown, M.H. (1995). «Cationic bactericidal peptides». Adv Microb Physiol. 37: 135–75 
  4. ↑ Amiche, M.; Ducoucel, F.; Boulain, J.C.; Menez, A.; Nicolas, P. (1994). «Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins». J Biol Chem. 269: 17847–17852 
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