5-Carboxamidotriptamina

A 5-Carboxamidotriptamina (5-CT) é uma droga que actua como agonista não-selectivo em diferentes receptores de serotonina. Era inicialmente pensado que seria selectivo para o 5HT1[1], mas pesquisas posteriores mostraram que também actua no 5HT2, no 5HT3,[2] no 5HT5 e no 5HT7[3], sendo no entanto o seu efeito maior no subtipo 5HT1A.[4] Apesar da sua falta de selectividade, a 5-CT é ainda um composto útil e é grandemente usado em pesquisas científicas.

Referências

  1. ↑ Saxena PR, Lawang A. A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors. Archives Internationales de Pharmacodynamie et de Therapie. 1985 Oct;277(2):235-52. PMID 2933009
  2. ↑ Wright CE, Angus JA. 5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets. Journal of Cardiovascular Pharmacology. 1989 Apr;13(4):557-64. PMID 2470992
  3. ↑ Yamada J, Sugimoto Y, Noma T, Yoshikawa T. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. European Journal of Pharmacology. 1998 Oct 16;359(1):81-6. PMID 9831297
  4. ↑ Thomas DR, Middlemiss DN, Taylor SG, Nelson P, Brown AM. 5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors. British Journal of Pharmacology. 1999 Sep;128(1):158-64. PMID 10498847


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