Domena białka

Domena białka – fragment cząsteczki białka wyodrębniony ze względu na samoistną zdolność zachowania swojej struktury trójwymiarowej niezależnie od całej cząsteczki.

Często domeny samoistnie zwijają się (ang. folding) z nowo wyprodukowanego łańcucha białka. Te same domeny często są obserwowane w różnych białkach. Mogą ulegać powieleniu (kilka takich samych domen w tym samym białku położonych jedna za drugą w łańcuchu białkowym).

Stanowią podstawowe funkcjonalne cegiełki w cząsteczce białka (np. domena kalmoduliny wiążąca wapń).

Do wykrywania domen używane są:

  • przyrównanie sekwencyjne (ang. sequence alignment),
  • przyrównanie strukturalne (ang. structural alignment).

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