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Pro-opiomelanocortine derivaten

POMC

γ-MSH

CLIP

Het corticotropin-like intermediate peptide (CLIP) ook bekend als corticotropinefragment 18-39 (ACTH(18-39)), is een natuurlijk voorkomend, endogeen neuropeptide met een structuur van 22 peptiden en de aminozuursequentie Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP wordt gegenereerd als een proteolytisch splitsingsproduct van corticotropine (ACTH),^[1]^[2] dat op zijn beurt een splitsingsproduct is van pro-opiomelanocortine (POMC).^[3] De fysiologische rol ervan is onderzocht in verschillende weefsels,^[4]^[5] met name in het centrale zenuwstelsel.^[6]^[7]^[8]^[9]^[10]

Er is voorgesteld dat het functioneert als een insuline secretagoog in de alvleesklier.^[11]

Bronnen, noten en/of referenties

↑ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia. The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883. DOI: 10.1016/S0021-9258(19)86402-5.
↑ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press, pp. 78. ISBN 978-0-8493-8852-1. Geraadpleegd op 25 november 2011.
↑ Hormones. Academic Press (26 september 1997), 12. ISBN 978-0-12-521441-4. Geraadpleegd op 25 november 2011.
↑ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. The Journal of Clinical Investigation 74 (5): 1886–9. PMID 6209301. PMC 425369. DOI: 10.1172/JCI111608.
↑ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain. Brain Research Bulletin 26 (1): 99–111. PMID 1849784. DOI: 10.1016/0361-9230(91)90194-O.
↑ Biology of sleep substances. CRC Press (1989), pp. 136. ISBN 978-0-8493-4822-8. Geraadpleegd op 25 november 2011.
↑ Chastrette N, Cespuglio R, Jouvet M (February 1990). Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives. Neuropeptides 15 (2): 61–74. PMID 1981927. DOI: 10.1016/0143-4179(90)90042-w.
↑ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes. Neuropeptides 15 (2): 75–88. PMID 1964203. DOI: 10.1016/0143-4179(90)90043-x.
↑ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain. Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852. DOI: 10.1007/s10517-009-0499-x.
↑ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]. Peptides 14 (6): 1221–4. PMID 8134304. DOI: 10.1016/0196-9781(93)90179-K.
↑ Marshall, J. B., Kapcala, L. P., Manning, L. D., McCullough, A. J. (November 1984). Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. The Journal of Clinical Investigation 74 (5): 1886–1889. ISSN: 0021-9738. PMID 6209301. PMC 425369. DOI: 10.1172/JCI111608.

[pmid227883-1] Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia. The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883. DOI: 10.1016/S0021-9258(19)86402-5.

[Fricker1991-2] Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press, pp. 78. ISBN 978-0-8493-8852-1. Geraadpleegd op 25 november 2011.

[NormanLitwack1997-3] Hormones. Academic Press (26 september 1997), 12. ISBN 978-0-12-521441-4. Geraadpleegd op 25 november 2011.

[pmid6209301-4] Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. The Journal of Clinical Investigation 74 (5): 1886–9. PMID 6209301. PMC 425369. DOI: 10.1172/JCI111608.

[pmid1849784-5] Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain. Brain Research Bulletin 26 (1): 99–111. PMID 1849784. DOI: 10.1016/0361-9230(91)90194-O.

[InouéInoué1989-6] Biology of sleep substances. CRC Press (1989), pp. 136. ISBN 978-0-8493-4822-8. Geraadpleegd op 25 november 2011.

[pmid1981927-7] Chastrette N, Cespuglio R, Jouvet M (February 1990). Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives. Neuropeptides 15 (2): 61–74. PMID 1981927. DOI: 10.1016/0143-4179(90)90042-w.

[pmid1964203-8] Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes. Neuropeptides 15 (2): 75–88. PMID 1964203. DOI: 10.1016/0143-4179(90)90043-x.

[pmid19529852-9] Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain. Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852. DOI: 10.1007/s10517-009-0499-x.

[pmid8134304-10] Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]. Peptides 14 (6): 1221–4. PMID 8134304. DOI: 10.1016/0196-9781(93)90179-K.

[11] Marshall, J. B., Kapcala, L. P., Manning, L. D., McCullough, A. J. (November 1984). Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules. The Journal of Clinical Investigation 74 (5): 1886–1889. ISSN: 0021-9738. PMID 6209301. PMC 425369. DOI: 10.1172/JCI111608.

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Corticotropin-like intermediate peptide