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Gabapentin

Endrika:Infobox drug Ny Gabapentin, amidy amin'ny anarana marika Neurontin ankoatra ny hafa, dia fanafody anticonvulsant ampiasaina hitsaboana ny androbe ampahany, ny fanaintainana neuropathique, ny hafanana tampoka, ary ny restless legs syndrome.[1][2] Aroso ho iray amin'ireo fanafody laharana voalohany amin'ny fitsaboana ny fanaintainan'ny nerveo vokatry ny neuropathy diabetika, ny neuralgia postherpetika, ary ny fanaintainan'ny nerveo afovoany izy io.[3] Manodidina ny 15%-n'ny olona voan'ny neuropathy diabetika na neuralgia postherpetika no manana tombony azo refesina.[4] Gabapentin dia raisina am-bava.[1]

Anisan'ny voka-dratsiny mahazatra ny fahatsapana rendremana sy ny fanina.[1] Anisan'ny voka-dratsiny lehibe ny fitomboan'ny mety hisian'ny famonoan-tena, ny fitondran-tena mahery setra, ary ny fihetseham-po vokatry ny fanafody.[1] Tsy mazava raha azo antoka ampiasaina mandritra ny fitondrana vohoka na ny fampinonoana izy io.[5] Aroso ny fatra ambany kokoa ho an'ireo olona tsy dia miasa tsara ny voa.[1] Gabapentin dia gabapentinoïde.[6] Manana rafitra molekiola mitovy amin'ny an'ny neurotransmitter γ-aminobutyric acid (GABA) izy ary miasa amin'ny alàlan'ny fanakanana ny fantsona kalsioma sasany.[7][6][8]

Nekena voalohany hampiasaina tamin'ny 1993 ny Gabapentin.[9][10] Efa azo ampiasaina ho fanafody tsy misy fangarony any Etazonia izy io nanomboka tamin'ny taona 2004.[1] Ny vidin'ny ambongadiny any amin'ny firenena an-dalam-pandrosoana as of 2015 teo amin'ny Endrika:USD isam-bolana teo ho eo; [11] tany Etazonia, dia 100 dolara amerikana ka hatramin'ny 200 dolara amerikana izany.[12] Tamin'ny taona 2017, io no fanafody fahiraika ambin'ny folo be mpampiasa indrindra any Etazonia, miaraka amin'ny fanafody mihoatra ny 46 tapitrisa.[13][14] Nandritra ny taona 1990, nanomboka nampiasa teknika tsy ara-dalàna maromaro ny Parke-Davis, sampan'ny Pfizer, mba hampirisihana ny dokotera any Etazonia hampiasa gabapentin amin'ny fampiasana tsy nahazoana alalana.[15] Nandoa vola an-tapitrisany dolara izy ireo mba handaminana ny fitoriana momba ireo hetsika ireo.

References

  1. ↑ 1,0 1,1 1,2 1,3 1,4 et 1,5 "Gabapentin". The American Society of Health-System Pharmacists. Archived from the original on 19 August 2017. Retrieved 23 Oct 2015.
  2. ↑ "Restless legs syndrome: clinical presentation diagnosis and treatment". Sleep Medicine 16 (6): 678–90. June 2015. doi:10.1016/j.sleep.2015.03.002. PMID 25979181. 
  3. ↑ "EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision". European Journal of Neurology 17 (9): 1113–e88. September 2010. doi:10.1111/j.1468-1331.2010.02999.x. PMID 20402746. 
  4. ↑ "Gabapentin for chronic neuropathic pain in adults". The Cochrane Database of Systematic Reviews 6: CD007938. June 2017. doi:10.1002/14651858.CD007938.pub4. PMC 6452908. PMID 28597471. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6452908. 
  5. ↑ "Gabapentin Pregnancy and Breastfeeding Warnings". Archived from the original on 29 August 2017. Retrieved 13 March 2016.
  6. ↑ 6,0 et 6,1 "2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use". Expert Review of Neurotherapeutics 16 (11): 1263–1277. November 2016. doi:10.1080/14737175.2016.1202764. PMID 27345098. 
  7. ↑ Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons, 219–220.
  8. ↑ "Acute modulation of calcium currents and synaptic transmission by gabapentinoids". Channels 4 (6): 490–6. 2010. doi:10.4161/chan.4.6.12864. PMID 21150315. 
  9. ↑ Pitkänen, Asla (2005). Models of Seizures and Epilepsy. Burlington: Elsevier.
  10. ↑ "Neurontin- gabapentin capsule Neurontin- gabapentin tablet, film coated Neurontin- gabapentin solution". DailyMed. 11 April 2019. Archived from the original on 7 July 2020. Retrieved 21 December 2019.
  11. ↑ "Gabapentin". International Drug Price Indicator Guide. Archived from the original on 12 June 2018. Retrieved 13 March 2016.
  12. ↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning.
  13. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  14. ↑ "Gabapentin - Drug Usage Statistics". ClinCalc. 23 December 2019. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
  15. ↑ "Safeguarding patient welfare: who's in charge?". Annals of Internal Medicine 145 (4): 305–7. August 2006. doi:10.7326/0003-4819-145-4-200608150-00013. PMID 16908923. 

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