항NMDA 수용체 뇌염

항NMDA 수용체 뇌염
다른 이름NMDA 수용체 항체 뇌염, 항-N-메틸-D-아스파르트산 수용체 뇌염, 항-NMDAR 뇌염
NMDA 수용체의 모식도
진료과신경과
증상초기: 발열, 두통, 피로감, 정신증, 불안[1][2]
후기: 발작, 호흡저하, 자율신경실조증[1]
합병증장기적인 정신적 또는 행동적 문제[2]
통상적 발병 시기며칠에서 몇 주 동안[3]
위험 인자난소 기형종, 불명[1][4]
진단 방식뇌척수액 내의 특정 항체[1]
유사 질병바이러스성 뇌염, 정신증, 악성증후군[2]
치료면역억제제, 수술[1]
투약코르티코스테로이드, 면역글로불린 요법 (IVIG), 혈장분리교환술, 아자싸이오프린[2]
예후일반적으로 양호 (치료 필요)[1]
빈도희귀함[2]
사망사망 위험 약 4%[2]

항NMDA 수용체 뇌염(영어: Anti-NMDA receptor encephalitis)은 항체로 인해 발생하는 뇌염의 일종이다.[4] 초기 증상으로는 발열, 두통, 피로감 등이 있다.[1][2] 그 다음에는 일반적으로 정신증이 뒤다르는데, 이러한 정신증은 잘못된 믿음(망상)과 다른 사람들이 보거나 듣지 못하는 것을 보거나 듣는 것(환각)을 특징으로 한다.[1] 사람들은 종종 불안해하거나 혼란스러워하기도 한다.[1] 시간이 지남에 따라 발작, 호흡저하, 자율신경실조증이 일반적으로 발생한다.[1] 어떤 경우에는 환자에게 긴장증이 생길 수 있다.[5]

같이 보기

각주

  1. ↑ 가 나 다 라 마 바 사 아 자 차 Kayser MS, Dalmau J (September 2016). “Anti-NMDA receptor encephalitis, autoimmunity, and psychosis”. 《Schizophrenia Research》 176 (1): 36–40. doi:10.1016/j.schres.2014.10.007. PMC 4409922. PMID 25458857. 
  2. ↑ 가 나 다 라 마 바 사 Kayser MS, Dalmau J (2011). “Anti-NMDA Receptor Encephalitis in Psychiatry”. 《Current Psychiatry Reviews》 7 (3): 189–193. doi:10.2174/157340011797183184. PMC 3983958. PMID 24729779. 
  3. ↑ Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE (2013). 《Abeloff's Clinical Oncology E-Book》 (영어). Elsevier Health Sciences. 600쪽. ISBN 978-1-4557-2881-7. 
  4. ↑ 가 나 Venkatesan A, Adatia K (December 2017). “Anti-NMDA-Receptor Encephalitis: From Bench to Clinic”. 《ACS Chemical Neuroscience》 8 (12): 2586–2595. doi:10.1021/acschemneuro.7b00319. PMID 29077387. 
  5. ↑ Wu H, Wu C, Zhou Y, Huang S, Zhu S (February 2023). “Catatonia in adult anti-NMDAR encephalitis: an observational cohort study”. 《BMC Psychiatry》 23 (1): 94. doi:10.1186/s12888-022-04505-x. PMC 9903498. PMID 36750806. 

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