류코시딘

류코시딘 (백혈구파괴소, 백혈구독(毒), 로이코시딘, leukocidin)은 몇몇 종류의 세균(포도상구균)에 의해 만들어지는 세포 독소의 종류이다. 이 독소는 PFT(pore forming toxin)의 한 종류로, 숙주 세포의 인지질 이중막에 구멍을 뚫는 독소이다.[1]

류코시딘의 이름은 백혈구(leukocyte)를 죽인다(-cide)는 뜻이다. 식세포,[1] 자연살해세포, 수지상세포, T세포를 표적으로 한다.[2] 류코시딘은 세균성 인베이신(invasin)의 종류에 속한다. 인베이신은 세균이 숙주 조직에 붙었을 때 침입을 도와주는 효소를 분비한다. 이는 외독소와 두 가지 측면에서 구별된다. 외독소와는 달리 덜 특정된(less specific) 메커니즘으로 작용하며, 그 독소의 작용이 보다 더 국소적(localized)이다.

대표적인 한 가지 유형으로 팬톤-발렌타인 류코시딘(Panton-Valentin leukocidin, PVL)이 있다.

각주

  1. ↑ 가 나 Alonzo, Francis; Torres, Victor J. (2014년 5월 20일). “The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus”. 《Microbiology and Molecular Biology Reviews》 78 (2): 199–230. doi:10.1128/mmbr.00055-13. ISSN 1092-2172. PMC 4054254. PMID 24847020. 
  2. ↑ Alonzo III, Francis; Kozhaya, Lina; Rawlings, Stephen A.; Reyes-Robles, Tamara; DuMont, Ashley L.; Myszka, David G.; Landau, Nathaniel R.; Unutmaz, Derya; Torres, Victor J. (2012년 12월 12일). “CCR5 is a receptor for Staphylococcus aureus leukotoxin ED”. 《Nature》 493 (7430): 51–55. doi:10.1038/nature11724. ISSN 0028-0836. PMC 3536884. PMID 23235831. 

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