3(or17)β-ヒドロキシステロイドデヒドロゲナーゼ

3(or17)β-ヒドロキシステロイドデヒドロゲナーゼ
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EC番号 1.1.1.51
CAS登録番号 9015-81-0
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3(or17)β-ヒドロキシステロイドデヒドロゲナーゼ（3(or 17)β-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。

テストステロン + NAD(P)+ アンドロスタ-4-エン-3,17-ジオン + NAD(P)H + H+

反応式の通り、この酵素の基質はテストステロンとNAD(P)+、生成物はアンドロスタ-4-エン-3,17-ジオンとNAD(P)HとH+である。

組織名は3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductaseで、別名にβ-hydroxy steroid dehydrogenase, 17-ketoreductase, 17β-hydroxy steroid dehydrogenas, 3β-hydroxysteroid dehydrogenase, 17β-hydroxy steroid dehydrogenase, 3β-hydroxy steroid dehydrogenaseがある。

参考文献

  • Dahm, K. and Breuer, H. (1964). “Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte”. Hoppe-Seyler's Z. Physiol. Chem. 336: 63–68. PMID 14214322. 
  • Lynn, W.S. and Brown, R.H. (1958). The conversion of progesterone to androgens by testes. 232. pp. 1015–1030. PMID 13549484. 
  • Marcus, P.I. and Talalay, P. (1956). “Induction and purification of α- and β-hydroxysteroid dehydrogenases”. J. Biol. Chem. 218. 
  • Schultz, R.M., Groman, F.V. and Engel, L.L. (1977). “3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms”. J. Biol. Chem. 252: 3775–3783. PMID 193845. 
  • Talalay, P. and Dobson, M.M. (1953). “Purification and properties of a α-hydroxysteroid dehydrogenase”. J. Biol. Chem. 205: 823–837. 

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