Sindrome di Sweet

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Sindrome di Sweet
Lesioni papulo-nodulari con necrosi centrale in paziente affetto.
Specialitàdermatologia
Classificazione e risorse esterne (EN)
ICD-9-CM695.89
ICD-10L98.2
OMIM608068
MeSHD016463
Sinonimi
Dermatosi acuta febbrile neutrofila

La sindrome di Sweet è stata descritta per la prima volta nel 1964 da Robert Douglas Sweet. La malattia, il cui termine scientifico è dermatosi acuta febbrile neutrofila, è una malattia che compare nel giro di pochi giorni per ragioni spesso ignote; si ritiene che essa si manifesti dopo l'esposizione del corpo ad alcuni stimoli, farmaci, tumori o infezioni.

Profilo clinico

La sindrome di Sweet si manifesta normalmente con lesioni dure e dolenti papulo-nodulari di colore violaceo; esse si formano su entrambe le metà del corpo. Le parti più colpite sono il viso, il collo e gli arti (superiori ed inferiori). La dermatosi è spesso accompagnata o preceduta da sensazioni di malessere, leucocitosi neutrofile, dolori articolari, febbre elevata, ipersedimetria e congiuntivite. La sindrome di Sweet viene normalmente preceduta da infezioni delle vie aeree e viene associata molte volte a tumori o malattie autoimmuni.

Profilo diagnostico

La sindrome di Sweet viene normalmente diagnosticata attraverso la comparsa di lesioni papulo-nodulari violacee, febbre o infezioni, dolori articolari, leucocitosi neutrofila e congiuntivite. Una biopsia cutanea dimostrerebbe la presenza nel derma reticolare di un infiltrato neutrofilo.

Terapia

Al paziente affetto dalla sindrome di Sweet viene normalmente prescritta una cura a base di cortisone, assunto per via sistemica.

Bibliografia

  • Dott. P. R. Cohen (Luglio 2007), Sweet's syndrome, a comprehensive review of an acute febrile neutrophilic dermatosis.

Altri progetti

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