MRC-5

Cellula MRC-5

MRC-5 (Ceppo cellulare 5 del Medical Research Council) è una linea di coltura cellulare diploide composta da fibroblasti, originariamente sviluppata dal tessuto polmonare di un feto maschio caucasico abortito di 14 settimane.[1][2] La linea cellulare è stata isolata da JP Jacobs e colleghi nel settembre 1966 dalla settima popolazione duplicata dal ceppo originale, e le stesse cellule MRC-5 sono conosciute per raggiungere la senescenza attorno alle 45 duplicazioni di popolazione.[3][4]

Applicazioni

Le cellule MRC-5 sono attualmente utilizzate per produrre diversi vaccini tra cui l'epatite A, la varicella e la poliomielite .[5]

Note

  1. ^ atcc.org, http://www.atcc.org/Products/All/CCL-171.aspx.
  2. ^ catalog.coriell.org, https://catalog.coriell.org/0/Sections/Search/Sample_Detail.aspx?Ref=AG05965-D.
  3. ^ J. P. Jacobs, C. M. Jones e J. P. Baille, Characteristics of a Human Diploid Cell Designated MRC-5, in Nature, vol. 227, n. 5254, 1970, pp. 168-70, DOI:10.1038/227168a0, PMID 4316953.
  4. ^ J. P. Jacobs, The Status of Human Diploid Cell Strain MRC-5 as an Approved Substrate for the Production of Viral Vaccines, in Journal of Biological Standardization, vol. 4, n. 2, 1976, pp. 97-99, DOI:10.1016/0092-1157(76)90018-4, PMID 932048.
  5. ^ sciencemag.org, https://www.sciencemag.org/news/2017/01/fact-checking-congress-s-fetal-tissue-report.

Collegamenti esterni

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