MAP2
| MAP2 | |
|---|---|
| Gene | |
| HUGO | MAP2 DKFZp686I2148; MAP2A; MAP2B; MAP2C |
| Locus | Chr. 2 q34 |
| Proteina | |
| OMIM | 157130 |
| UniProt | P11137 |
La Proteina associata ai microtubuli 2 (MAP2) è una proteina che nell'uomo è codificata dal gene MAP2[1][2].
Questo gene codifica una proteina che appartiene alla famiglia delle proteine associate ai microtubuli. Le proteine di questa famiglia si pensa siano essere implicate nella costruzione dei microtubuli, che è un passaggio essenziale nella neurogenesi. MAP2 serve a stabilizzare l'accrescimento dei microtubuli (MT) tramite un ponte tra il MT con i filamenti intermedi e altri MT. I prodotti del gene simile nei ratti e topi sono proteine citoscheletriche neurone-specifico che sono maggiormente presenti nei dendriti, implica un ruolo determinante e stabilizzante della forma del neurone durante lo sviluppo. Un numero di splicing alternativo variabile codifica per distinte isoforme[3].
Uno studio del 2019 dimostra che una mutazione in MAP2 è associata alla densità del follicolo pilifero prenatale[4].
Interazioni
MAP2 è stato dimostrato interagire con Grb2,[5][6] NEFL[7] e MYO7A.[8]
Note
- ^ Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2". Brain Res 387 (3): 271-80. PMID 3103857
- ^ Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (Dec 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms". Proc Natl Acad Sci U S A 92 (24): 10894-8. PMID 7479905.
- ^ Entrez Gene: MAP2 microtubule-associated protein 2, su ncbi.nlm.nih.gov.
- ^ Yao Jiang, Yifan Jiang e Haihan Zhang, A mutation in MAP2 is associated with prenatal hair follicle density, in The FASEB Journal, 7 novembre 2019, pp. fj.201901187R, DOI:10.1096/fj.201901187R. URL consultato il 24 novembre 2019.
- ^ R W Lim, Halpain S, Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein, in J. Biol. Chem., vol. 275, n. 27, UNITED STATES, luglio 2000, pp. 20578-87, DOI:10.1074/jbc.M001887200, ISSN 0021-9258, PMID 10781592.
- ^ S P Zamora-Leon, Lee G, Davies P, Shafit-Zagardo B, Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2, in J. Biol. Chem., vol. 276, n. 43, United States, ottobre 2001, pp. 39950-8, DOI:10.1074/jbc.M107807200, ISSN 0021-9258, PMID 11546790.
- ^ T Frappier, Stetzkowski-Marden F, Pradel L A, Interaction domains of neurofilament light chain and brain spectrin, in Biochem. J., 275 (Pt 2), ENGLAND, aprile 1991, pp. 521-7, ISSN 0264-6021, PMID 1902666.
- ^ P T Todorov, Hardisty R E, Brown S D, Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B), in Biochem. J., vol. 354, Pt 2, England, marzo 2001, pp. 267-74, ISSN 0264-6021, PMID 11171103.
Bibliografia
- Roses AD, Einstein G, Gilbert J, et al., Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism., in Ann. N. Y. Acad. Sci., vol. 777, 1996, pp. 146–57, DOI:10.1111/j.1749-6632.1996.tb34413.x, PMID 8624078.
- Snásel J, Pichová I, The cleavage of host cell proteins by HIV-1 protease., in Folia Biol. (Praha), vol. 42, n. 5, 1997, pp. 227–30, DOI:10.1007/BF02818986, PMID 8997639.
- Shafit-Zagardo B, Kalcheva N, Making sense of the multiple MAP-2 transcripts and their role in the neuron., in Mol. Neurobiol., vol. 16, n. 2, 1999, pp. 149–62, DOI:10.1007/BF02740642, PMID 9588626.
- Liu Y, Saad RS, Shen SS, Silverman JF, Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms., in Advances in anatomic pathology, vol. 10, n. 2, 2003, pp. 101–6, DOI:10.1097/00125480-200303000-00005, PMID 12605092.
- Ainsztein AM, Purich DL, Cleavage of bovine brain microtubule-associated protein-2 by human immunodeficiency virus proteinase., in J. Neurochem., vol. 59, n. 3, 1992, pp. 874–80, DOI:10.1111/j.1471-4159.1992.tb08325.x, PMID 1494913.
- Alberts MJ, Kandt RS, Pericak-Vance MA, et al., MspI RFLP for microtubule associated protein-2 (MAP2)., in Nucleic Acids Res., vol. 19, n. 4, 1991, p. 960, DOI:10.1093/nar/19.4.960, PMID 1708129.
- Wallin M, Deinum J, Goobar L, Danielson UH, Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases., in J. Gen. Virol., 71 (Pt 9), 1990, pp. 1985–91, DOI:10.1099/0022-1317-71-9-1985, PMID 2212989.
- Kosik KS, Orecchio LD, Bakalis S, et al., Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles., in J. Neurochem., vol. 51, n. 2, 1988, pp. 587–98, DOI:10.1111/j.1471-4159.1988.tb01079.x, PMID 2455776.
- Dammerman M, Yen SH, Shafit-Zagardo B, Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles., in J. Neurosci. Res., vol. 24, n. 4, 1990, pp. 487–95, DOI:10.1002/jnr.490240405, PMID 2481044.
- Obar RA, Dingus J, Bayley H, Vallee RB, The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C., in Neuron, vol. 3, n. 5, 1990, pp. 639–45, DOI:10.1016/0896-6273(89)90274-2, PMID 2561973.
- Rubino HM, Dammerman M, Shafit-Zagardo B, Erlichman J, Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2., in Neuron, vol. 3, n. 5, 1990, pp. 631–8, DOI:10.1016/0896-6273(89)90273-0, PMID 2701845.
- Herrmann H, Wiche G, Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin., in J. Biol. Chem., vol. 262, n. 3, 1987, pp. 1320–5, PMID 3027087.
- Garner CC, Tucker RP, Matus A, Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites., in Nature, vol. 336, n. 6200, 1989, pp. 674–7, DOI:10.1038/336674a0, PMID 3200318.
- Takahashi M, Tomizawa K, Sato K, et al., A novel tau-tubulin kinase from bovine brain., in FEBS Lett., vol. 372, n. 1, 1995, pp. 59–64, DOI:10.1016/0014-5793(95)00955-9, PMID 7556643.
- Kindler S, Garner CC, Four repeat MAP2 isoforms in human and rat brain., in Brain Res. Mol. Brain Res., vol. 26, n. 1-2, 1995, pp. 218–24, DOI:10.1016/0169-328X(94)90093-0, PMID 7854050.
- Albala JS, Kalcheva N, Shafit-Zagardo B, Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2)., in Gene, vol. 136, n. 1-2, 1994, pp. 377–8, DOI:10.1016/0378-1119(93)90502-T, PMID 8294038.
- Illenberger S, Drewes G, Trinczek B, et al., Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics., in J. Biol. Chem., vol. 271, n. 18, 1996, pp. 10834–43, DOI:10.1074/jbc.271.18.10834, PMID 8631898.
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