Glembatumumab vedotin

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Glembatumumab vedotin
Caratteristiche generali
Numero CAS1020264-78-1 (riferito al glembatumumab)
Indicazioni di sicurezza
Modifica dati su Wikidata · Manuale

Il glembatumumab vedotin o CDX-011 o CR011-vcMMAE è un anticorpo monoclonale di tipo umano coniugato ad un farmaco (ADC): il monometil auristatin E (MMAE). Viene studiato nel trattamento del melanoma[1][2] e del tumore della mammella.[3][4]

Il farmaco agisce sull'antigene: GPNMB (proteina transmembrana NMB) delle cellule tumorali, l'ADC viene interiorizzato dentro la cellula tumorale, il legame è rotto e il MMAE viene rilasciato ed è in grado così di uccidere la cellula.[5]

Esso è stato sviluppato dalla Celldex Therapeutics Inc.

Note

  1. ^ X. Qian, E. Mills; M. Torgov; WJ. LaRochelle; M. Jeffers, Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011-vcMMAE antibody-drug conjugate., in Mol Oncol, vol. 2, n. 1, giugno 2008, pp. 81-93, DOI:10.1016/j.molonc.2008.02.002, PMID 19383330.
  2. ^ NCT00412828, su clinicaltrials.gov, 9 settembre 2009. URL consultato il 30 dicembre 2009.
    «A Phase I/II Study of CR011-vcMMAE in Subjects With Unresectable Stage III or Stage IV Melanoma»
  3. ^ AA. Rose, AA. Grosset; Z. Dong; C. Russo; PA. Macdonald; NR. Bertos; Y. St-Pierre; R. Simantov; M. Hallett; M. Park; L. Gaboury, Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer., in Clin Cancer Res, vol. 16, n. 7, aprile 2010, pp. 2147-56, DOI:10.1158/1078-0432.CCR-09-1611, PMID 20215530.
  4. ^ NCT00704158, su clinicaltrials.gov, 9 settembre 2009. URL consultato il 30 dicembre 2009.
    «Study of CR011-vcMMAE to Treat Locally Advanced or Metastatic Breast Cancer»
  5. ^ (EN) CuraGen Announces Expansion Of CR011-vcMMAE Phase II Trial In Advanced Breast Cancer, su medicalnewstoday.com (archiviato dall'url originale il 20 giugno 2009).

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