Colecalciferolo

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Colecalciferolo
formula di struttura
formula di struttura
Nome IUPAC
Colecalciferolo
Nomi alternativi
Vitamina D3
Caratteristiche generali
Formula bruta o molecolareC27H44O
Massa molecolare (u)384,64 g/mol
AspettoBianco, cristalli aghiformi
Numero CAS67-97-0
Numero EINECS200-673-2
PubChem5280795
DrugBankDBDB00169
SMILES
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Proprietà chimico-fisiche
Temperatura di fusione−114,3 °C (158,8 K) 83-86 °C (358,16 K)
Temperatura di ebollizione78,4 °C (351,5 K)
Indicazioni di sicurezza
Simboli di rischio chimico
tossicità acuta tossico a lungo termine
pericolo
Frasi H301 - 311 - 330 - 372
Consigli P260 - 280 - 284 - 301+310 - 310 [1]
Modifica dati su Wikidata · Manuale

Il colecalciferolo[2], chiamato anche vitamina D3, è una delle vitamine del gruppo D.

È strutturalmente uno steroide, con affinità strutturali con il testosterone, il colesterolo e il cortisolo.

Forme

Il colecalciferolo è presente in tre diverse forme biologiche:

  • il colecalciferolo vero e proprio, che è la forma inattiva e non idrossilata della vitamina D3;
  • il calcidiolo, che è la forma i cui valori vengono misurati nel sangue;
  • il calcitriolo, la forma biologicamente attiva della vitamina D3.

Il 7-deidrocolesterolo è il precursore biologico della vitamina D3, che viene trasformato in colecalciferolo dopo esposizione alla radiazione ultravioletta. La vitamina D svolge un ruolo cruciale per il controllo del metabolismo del calcio insieme con altri due ormoni, il paratormone e la calcitonina. Essa è in grado di stimolare l'assorbimento del calcio a livello gastro-intestinale. È secreta a partire da cellule della cute in seguito all'esposizione solare.

Carenza

Il colecalciferolo è importante anche perché un deficit di questa vitamina provoca rachitismo nel bambino e osteomalacia nell'adulto.

Note

  1. ^ Sigma Aldrich; rev. del 26.10.2012
  2. ^ Dibase - soluzione (Colecalciferolo), indicazioni, effetti collaterali, interazioni, terapia, su codifa.it. URL consultato il 15 aprile 2019.

Altri progetti

Collegamenti esterni

Controllo di autoritàThesaurus BNCF 51902 · LCCN (EN) sh2004001239 · J9U (EN, HE) 987007542378105171
  Portale Biologia

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