Boldina
| Boldina | |
|---|---|
 | |
| Nome IUPAC | |
| (8S)-1,13-dimetossi-7-metil-5,6,6a,7-tetraidro-4H-dibenzo[de,g]chinolin-2,12-diolo | |
| Caratteristiche generali | |
| Formula bruta o molecolare | C19H21NO4 |
| Massa molecolare (u) | 327,37 |
| Numero CAS | |
| Numero EINECS | 207-509-9 |
| PubChem | 10154 |
| SMILES | CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O |
| Proprietà chimico-fisiche | |
| Temperatura di fusione | 159-162 (miscela racemica) |
| Dati farmacocinetici | |
| Metabolismo | epatico[1] |
| Emivita | 31 min[1] |
| Indicazioni di sicurezza | |
La boldina è un alcaloide estratto dalle foglie del Peumus boldus (Monimiaceae)[2] e presente anche nella Lindera aggregata[3]. La boldina pura cristallizzata provoca un aumento della secrezione biliare superiore di cinque volte al volume secreto normalmente. Esplica un'intensa azione ipotensiva nel cane vagotomizzato.
Indicazioni terapeutiche
In passato estratti di boldo erano impiegati come coleretici; oggi trova ancora limitato impiego in preparazioni orali ad azione lassativa, in associazione con altri farmaci ed è oggetto di studi per le proprietà antiossidanti[4].
Note
- ^ a b I. Jiménez, H. Speisky, Biological disposition of boldine: in vitro and in vivo studies., in Phytother Res, vol. 14, n. 4, Jun 2000, pp. 254-60, PMID 10861968.
- ^ Peter O’Brien, Catalina Carrasco-Pozo, Hernán Speisky, Boldine and its antioxidant or health-promoting properties, in Chemico-Biological Interactions, vol. 159, n. 1, 2006, pp. 1–17, DOI:10.1016/j.cbi.2005.09.002.
- ^ Zheng Han, Yunliang Zheng, Na Chen, Lianjun Luan, Changxin Zhou, Lishe Gan, Simultaneous determination of four alkaloids in Lindera aggregata by ultra-high-pressure liquid chromatography–tandem mass spectrometry, in Journal of Chromatography A, vol. 1212, n. 1-2, 2008, pp. 76–81, DOI:10.1016/j.chroma.2008.10.017.
- ^ Hernan Speisky, Bruce K. Cassels, Boldo and boldine: an emerging case of natural drug development, in Pharmacological Research, vol. 29, n. 1, 1994, pp. 1–12, DOI:10.1016/1043-6618(94)80093-6.
Bibliografia
- Bourgoin, Verne, J. Pharm. Chim. 16, 191, 1872
- Karl Bernauer, Über Alkaloide ausLaurelia novae-zelandiae A. CUNN. 5. Mitteilung Über natürliche und synthetische Isochinolinderivate, in Helvetica Chimica Acta, vol. 50, n. 6, 1967, pp. 1583–1588, DOI:10.1002/hlca.19670500617.
- S. Morris Kupchan, Chang-Kyu Kim, Katsuji Miyano, Novel photochemical aporphine synthesis via spirodienone rearrangement: (±)-boldine, in Journal of the Chemical Society, Chemical Communications, n. 3, 1976, p. 91, DOI:10.1039/c39760000091.
- Dewan S. Bhakuni, Shobha Tewari, Randhir S. Kapil, Biosynthesis of boldine (1,10-dimethoxy-6a?-aporphine-2,9-diol), in Journal of the Chemical Society, Perkin Transactions 1, n. 6, 1977, p. 706, DOI:10.1039/p19770000706.
- H. Schindler, Arzneimittel-Forsch. 7, 747, 1957.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.