Annessina A1

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Annessina A1
Gene
Entrez301
LocusChr. 9 [1]
Proteina
OMIM151690
Modifica dati su Wikidata · Manuale

L'annessina A1, conosciuta anche come lipocortina 1, è una proteina codificata dal gene ANXA1, situato sul cromosoma 9 umano.

La proteina possiede proprietà antinfiammatorie perché è in grado di sopprimere sia l'attività della fosfolipasi A2 sià l'attività leucocitaria.

Ruolo

Si lega ai recettori per il formil-peptide e attraverso ciò può essere responsabile dello sviluppo di metastasi.[1]

Essa svolge anche un ruolo nella guarigione della mucosa gastrica.[2] È secreta dalle cellule digerenti nel caso di rettocolite ulcerosa e altre malattie infiammatorie intestinali [3] e sono in grado di agire nella sedazione del processo infiammatorio.

La sua espressione genica è stimolata da glucocorticoidi per un'azione anti-infiammatoria e viene abbondantemente prodotta dai granulociti neutrofili.[4]

A livello cellulare, è stimolata dagli ioni calcio, si lega ai fosfolipidi di membrana cellulare, contribuendo a ripararla.[5]

Note

  1. ^ Babbin BA, Lee WY, Parkos CA et al. Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors, J Biol Chem, 2006;281:19588–19599
  2. ^ Martin GR, Perretti M, Flower RJ, Wallace JL, Annexin-1 modulates repair of gastric mucosal injury (archiviato dall'url originale il 3 marzo 2016), Am J Physiol Gastrointest Liver Physiol, 2008;294:G764–G769
  3. ^ Leoni G, Neumann PA, Kamaly N et al. Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair, J Clin Invest, 2015;125:1215–1227
  4. ^ Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY, Perretti M, Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles, Blood, 2008;112:2512–2519
  5. ^ McNeil AK, Rescher U, Gerke V, McNeil PL, Requirement for annexin A1 in plasma membrane repair, J Biol Chem, 2006;281:35202–35207
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