25-idrossicolesterolo 7alfa-idrossilasi

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25-idrossicolesterolo 7alfa-idrossilasi
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Numero EC1.14.13.100
ClasseOssidoreduttasi
Nome sistematico
colest-5-ene-3β,25-diolo,NADPH:ossigeno ossidoreduttasi (7α-idrossilante)
Altri nomi
25-idrossicolesterolo 7α-monoossigenasi; CYP7B1; CYP7B1 ossisterolo 7α-idrossilasi
Banche datiBRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum)
Fonte: IUBMB
Modifica dati su Wikidata · Manuale

La 25-idrossicolesterolo 7alfa-idrossilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione:

colest-5-ene-3β,25-diolo + NADPH + H+ + O2 ⇄ colest-5-ene-3β,7α,25-triolo + NADP+ + H2O
colest-5-ene-3β,27-diolo + NADPH + H+ + O2 ⇄ colest-5-ene-3β,7α,27-triolo + NADP+ + H2O

L'enzima è una proteina eme-tiolata (P-450). A differenza della 24-idrossicolesterolo 7alfa-idrossilasi (numero EC 1.14.13.99[1]), che è specifica per il suo substrato ossisterolo, questo enzima può anche metabolizzare gli ossisteroli 24,25-epossicolesterolo, 22-idrossicolesterolo ed il 24-idrossicolesterolo, ma con minore risultato.

Note

  1. ^ (EN) 1.14.13.99, in ExplorEnz — The Enzyme Database, IUBMB.

Bibliografia

  • Li-Hawkins, J., Lund, E.G., Bronson, A.D. and Russell, D.W., Expression cloning of an oxysterol 7α-hydroxylase selective for 24-hydroxycholesterol, in J. Biol. Chem., vol. 275, 2000, pp. 16543–16549, Entrez PubMed 10748047.
  • Ren, S., Marques, D., Redford, K., Hylemon, P.B., Gil, G., Vlahcevic, Z.R. and Pandak, W.M., Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat, in Metabolism, vol. 52, 2003, pp. 636–642, Entrez PubMed 12759897.
  • Toll, A., Wikvall, K., Sudjana-Sugiaman, E., Kondo, K.H. and Björkhem, I., 7α hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7α-hydroxylase, in Eur. J. Biochem., vol. 224, 1994, pp. 309–316, Entrez PubMed 7925343.
  • Russell, D.W., The enzymes, regulation, and genetics of bile acid synthesis, in Annu. Rev. Biochem., vol. 72, 2003, pp. 137–174, Entrez PubMed 12543708.

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