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ORG-25435

ORG-25435

  ORG-25435 bụ ọgwụ aka mepụtara site na Organon International, nke na-arụ ọrụ dị ka modulator allosteric nke GABAA, ma na-emepụta mmetụta sedative. A na-eme nnyocha maka iji ya mee ihe dị anụahụ mma maka nsogbụ ụra dị ka ihe na-akụnwụ ahụ, na nsonaazụ dị mma na nnwale mbụ, ọ bụ ezie na mmetụta ọjọọ dị ka hypotension na tachycardia, yana ọgwụ ndị a na-apụghị ịkọwapụta na doses dị elu, pụtara na emesịghị nabata ntụziaka di ka onye ya maka iji ọgwụ.[1][2]

Ntụaka

  1. ↑ (October 2001) "Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors". Journal of Medicinal Chemistry 44 (22): 3582–91. DOI:10.1021/jm010903i. PMID 11606122. 
  2. ↑ (June 2010) "First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial". BMC Anesthesiology 10: 10. DOI:10.1186/1471-2253-10-10. PMID 20587019. 

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