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Cidoxepin

Cidoxepin (aha koodu mmepe mbụ P-4599), nke a makwaara dị ka cis-doxepin ma ọ bụ (Z) -doxepin, bụ ọgwụ antidepressant tricyclic nke e mepụtara na 1960s mana ọ dịghị mgbe a na-ere ya.[1][2] Ọ bụ cis ma ọ bụ (Z) stereoisomer nke doxepin, ngwakọta nke (E) na (Z) isomers nke a na-eji azụmaahịa eme ihe na ihe dịka 85:15 na cidoxepin dị ka obere ihe.[1][3] Otú ọ dị, ọgwụ ahụ nwere onye isi oche nkeji nke ụmụaka hụrụ na mmiri nke dị ka ndị mmadụ nwere ọrụ yiri nke doxepin, na-arụ ọrụ dị ka serotonin-norepinephrine reuptake inhibitor, H1 antagonist anabata, na anticholinergic, ma karịsịa a na-eche na ọ nwere ọrụ antidepressant karịa trans-doxepin.[3][4][5] A kọọrọ na ọrụ mgbochi nke cidoxepin bụ okpukpu atọ karịa nke trans isomer na ụmụ oke.[5]

N'oge na-adịbeghị anya, Elorac, Inc. emeela nchọpụta ọzọ ma na-emepe ugbu a dị ka ihe na-egbochi histamine maka ọgwụgwọ nke urticaria na-adịghị ala ala (oge oyi).[4] Ka ọ na-erule afọ 2017, ọ nọ na nyocha ahụike nke abụọ maka ihe ngosi a.[4] A na-enyocha ọgwụ ahụ maka ọgwụgwọ nke rhinitis na-adịghị anabata (hay fever), atopic dermatitis (atopic eczema), na contact dermatitis, mana a kwụsịrị mmepe maka ihe ngosi ndị a.[4]

  • Esmirtazapine
  • Nordoxepin

Ntụaka

  1. ↑ 1.0 1.1 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer, 469–. ISBN 978-1-4757-2085-3. 
  2. ↑ (1969) "Doxepin versus diazepam: a controlled evaluation in 100 chronic alcoholic patients". J Clin Pharmacol J New Drugs 9 (1): 57–65. PMID 4885966. 
  3. ↑ 3.0 3.1 Shufeng Zhou (6 April 2016). Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism. CRC Press, 142–. ISBN 978-1-4665-9788-4. 
  4. ↑ 4.0 4.1 4.2 4.3 Cidoxepin - AdisInsight.
  5. ↑ 5.0 5.1 (2001) "Elimination of doxepin isomers from the horse following intravenous application". J. Vet. Pharmacol. Ther. 24 (4): 283–9. DOI:10.1046/j.1365-2885.2001.00345.x. PMID 11555184. 

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