Karbokromén

Karbokromén
IUPAC-név
etil-2-({3-[2-(dietilamino)etil]-4-metil-2-oxo-2H-kromén-7-il}oxi)acetát
Kémiai azonosítók
CAS-szám 804-10-4
PubChem 12604
ChemSpider 12084
ATC kód C01DX05
Gyógyszer szabadnév carbocromen
SMILES
O=C(OCC)COc2ccc\1c(OC(=O)/C(=C/1C)CCN(CC)CC)c2
InChI
1/C20H27NO5/c1-5-21(6-2)11-10-17-14(4)16-9-8-15(12-18(16) 26-20(17)23)25-13-19(22)24-7-3/ h8-9,12H,5-7,10-11,13H2,1-4H3
InChIKey KLOIYEQEVSIOOO-UHFFFAOYSA-N
UNII R0C9NIE5JJ
ChEMBL 163672
Kémiai és fizikai tulajdonságok
Kémiai képlet C20H27NO5
Moláris tömeg 361,43 g/mol
Sűrűség 1,126
Forráspont 488,6 °C
Terápiás előírások
Alkalmazás orális, intravénás, intramuszkuláris, belégzés


A karbokromén szívinfarktus kezelésére alkalmazott gyógyszer. Tágítja a koszorúereket, csökkenti az iszkémiás fájdalmat.[1] Nem növeli a vérnyomást még intravénás adagolásban sem. Segít normalizálni az infarktus utáni EKG-elváltozásokat. Gátolja a vérlemezkék összecsapzódását.[2]

Gátolja a foszfodiészteráz(en) enzimet.[3]

Mellékhatások

Étvágytalanság, hányinger, hányás, álmatlanság, fejfájás. Más mellékhatások is lehetségesek.

Adagolás

  • szájon át napi 3×75 vagy 3×150 mg
  • intravénásan vagy izomba: első két alkalommal 20–40 mg. Intravénásan szükség esetén 40–80 mg-ig el lehet menni. A gyors intravénás adagolás átmeneti arcpírt és szívdobogást okozhat, ezért az injekciót lassan, 10–20 ml 5%-os glükózoldattal kell beadni.
  • spray: naponta háromszor 2–3 belélegzés.

Készítmények

A nemzetközi gyógyszerkereskedelemben[4]

  • önállóan: Antiangor, Cassella 4489, Chromonar, Intenkordin
  • hidroklorid formában: Cardiocap, Cromene, Intensain
  • digoxinnal(en) kombinációban: Intensain-Lanicor
  • metildigoxinnal(en) kombinációban: Coro-Lanitop, Intensain-Lanitop
  • fenobarbitállal kombinációban: Seda-Intensain

Magyarországon nincs forgalomban.[5]

Jegyzetek

  1. ↑ A koszorúerek vérellátási zavara miatti mellkasi fájdalom.
  2. ↑ Resag K, Melzer G, Nitz RE.: Studies on inhibition of platelet aggregation by carbocromen (PubMed)
  3. ↑ Schraven E, Trottnow D, Fiedler VB.: The effect of carbocromen on cardiac cyclic adenosine-monophosphate (PubMed)
  4. ↑ Carbocromen (Drugs-About.com)
  5. ↑ Az OGYI adatbázisában még a hatóanyag sem szerepel.

Források

További információk

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