Ribonuclease III

Ribonuclease III
Identificadores
SímboloRNase_III
PfamPF00636
InterProIPR000999
PROSITEPDOC00448
SCOPe1jfz / SUPFAM

As ribonucleases III ou RNases III son encimas ribonucleases que se unen especificamente e clivan (cortan) ARNs bicatenarios.[1] Un exemplo é a ribonuclease III procariótica de Escherichia coli (EC 3.1.26.3) (xene rnc),[2] que é un encima que dixire ARN bicatenario, e está implicado no procesamento de precursores do ARN ribosómico e dalgúns ARNm.

Dentro das RNases III distínguense catro subdivisións, que son as clases 1, 2, 3, e 4.

Proteínas humanas que conteñen este dominio

DICER1; MRPL44; RNASEN;

Notas

  1. ↑ Lamontagne, B.; Larose, S.; Boulanger, J.; Elela, S. (2001). "The RNase III family: A conserved structure and expanding functions in eukaryotic dsRNA metabolism". Current issues in molecular biology 3 (4): 71–78. PMID 11719970. 
  2. ↑ Nashimoto H, Uchida H (1985). "DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations". Mol. Gen. Genet. 201 (1): 25–29. PMID 3903434. doi:10.1007/bf00397981. 
  3. ↑ Filippov V, Solovyev V, Filippova M, Gill SS (Mar 2000). "A novel type of RNase III family proteins in eukaryotes". Gene 245 (1): 213–221. PMID 10713462. doi:10.1016/S0378-1119(99)00571-5. 
  4. ↑ Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature 409 (6818): 363–6. PMID 11201747. doi:10.1038/35053110. 
  5. ↑ Glow, D.; Pianka, D.; Sulej, A. A.; Kozlowski, Lukasz P.; Czarnecka, J.; Chojnowski, G.; Skowronek, K. J.; Bujnicki, J. M. (2015). "Sequence-specific cleavage of dsRNA by Mini-III RNase". Nucleic Acids Research 43 (5): 2864–2873. ISSN 0305-1048. PMID 25634891. doi:10.1093/nar/gkv009. 

Véxase tamén

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