Minaprine

Identification
Minaprine

Nom UICPA	4-méthyl-N-(2-morpholin-4-yléthyl)-6-phénylpyridazin-3-amine
N^o CAS	25905-77-5
N^o ECHA	100.043.012
Code ATC	N06AX07
PubChem	4199
SMILES	CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3 PubChem, vue 3D
InChI	Std. InChI : vue 3D InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20) Std. InChIKey : LDMWSLGGVTVJPG-UHFFFAOYSA-N
Propriétés chimiques
Formule	C₁₇H₂₂N₄O
Masse molaire^[1]	298,382 8 ± 0,016 2 g/mol C 68,43 %, H 7,43 %, N 18,78 %, O 5,36 %,
Données pharmacocinétiques
Demi-vie d’élim.	2 à 2,5h
Considérations thérapeutiques
Voie d’administration	orale

Unités du SI et CNTP, sauf indication contraire.
modifier

La minaprine (Bantur, Cantor) est un antidépresseur qui a été utilisé en France dans le traitement de la dépression jusqu'à son retrait du marché en 1996 car il causait des convulsions^[2]. Il a été découvert par Henri Laborit qui l'appelait aussi Agr 1240^[3]. Un premier essai a eu lieu à la clinique de la Borde à Cour-Cheverny^[4]. Une étude a montré qu'il agit comme inhibiteur réversible de la monoamine oxydase chez les rats^[5]. Une autre étude a montré une diminution de l'activité de l'acétylcholine estérase dans le striatum de rats^[6].

Notes et références

↑ Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.
↑ (en) M. Fung, « Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999 », Therapeutic Innovation & Regulatory Science, vol. 35, n^o 1,‎ 1^er janvier 2001, p. 293–317 (DOI 10.1177/009286150103500134)
↑ Henri Laborit - Fabrice Rouleau : L'Alchimie de la Découverte (Grasset)
↑ Équipe soignante de la clinique de Cour-Cheverny. Coordonnateur : J.-P. Muyard. « Premiers essais cliniques de l'Agr 1240 » Agressologie 1972;13(4):337-52.
↑ (en) Kan JP, Mouget-Goniot C, Worms P, Biziere K, « Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat », Biochemical Pharmacology, vol. 35, n^o 6,‎ 1986, p. 973–978 (PMID 3954800)
↑ (en) Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG, « Aminopyridazines as acetylcholinesterase inhibitors », Journal of Medicinal Chemistry, vol. 42, n^o 4,‎ 1999, p. 730–41. (PMID 10052979, DOI 10.1021/jm981101z).

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