Holo-(acyl-carrier-protein) synthase

Titre correct : « Holo-[acyl-carrier-protein] synthase ».

En raison de limitations techniques, la typographie souhaitable du titre n’a pu être restituée correctement.

Holo-[acyl-carrier-protein] synthase
Description de cette image, également commentée ci-après
Homotrimère d'holo-ACP synthase d'Helicobacter pylori complexé avec la coenzyme A (en vert, PDB 5XUK)
N° EC EC 2.7.8.7
N° CAS 37278-30-1
Cofacteur(s) Magnésium
Activité enzymatique
IUBMB Entrée IUBMB
IntEnz Vue IntEnz
BRENDA Entrée BRENDA
KEGG Entrée KEGG
MetaCyc Voie métabolique
PRIAM Profil
PDB RCSB PDB PDBe PDBj PDBsum
GO AmiGO / EGO

modifier

L'holo-[acyl carrier protein] synthase, ou holo-ACP synthase (ACPS), est une transférase qui catalyse la réaction chimique :

Coenzyme A + apo-[acyl-carrier-protein]    adénosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].

Elle utilise le cation de magnésium Mg2+ comme cofacteur. Elle finalise la biosynthèse de l'acyl carrier protein en liant la phosphopantéthéine d'une coenzyme A à un résidu de sérine de l'apoprotéine pour former l'holoprotéine fonctionnelle.

Notes et références

  • (en) Elovson J, Vagelos PR, « Acyl carrier protein. X. Acyl carrier protein synthetase », J. Biol. Chem., vol. 243, no 13,‎ , p. 3603–11. PMID 4872726
  • (en) Prescott DJ, Vagelos PR, « Acyl carrier protein », Adv. Enzymol. Relat. Areas. Mol. Biol., vol. 36,‎ , p. 269–311. PMID 4561013
  • (en) Walsh CT, Gehring AM, Weinreb PH, Quadri LE, Flugel RS, « Post-translational modification of polyketide and nonribosomal peptide synthases », Curr. Opin. Chem. Biol., vol. 1, no 3,‎ , p. 309–15. DOI 10.1016/S1367-5931(97)80067-1 PMID 9667867
  • (en) Mootz HD, Finking R, Marahiel MA, « 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis », J. Biol. Chem., vol. 276, no 40,‎ , p. 37289–98. DOI 10.1074/jbc.M103556200 PMID 11489886
  • (en) Joshi AK, Zhang L, Rangan VS, Smith S, « Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity », J. Biol. Chem., vol. 278, no 35,‎ , p. 33142–9. DOI 10.1074/jbc.M305459200 PMID 12815048

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