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HGF
	Structure de la protéine HGF. Basé sur l'identifiant PDB 1BHT.
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
Identifiants
Aliases	HGF, Facteur de croissance des hépatocytes
IDs externes	OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF
Position du gène (Homme)
Chr.	Chromosome 7 humain
Fin	81,770,438 bp
Position du gène (Souris)
Chr.	Chromosome 5 (souris)
Fin	16,825,150 bp
Expression génétique
	Fortement exprimé dans
	placenta; ; stromal cell of endometrium; ; pleura viscéral; ; buccal mucosa cell; ; monocyte; ; pancreatic epithelial cell; ; vésicule biliaire; ; Epithelium of choroid plexus; ; foie; ; artère coronaire droite;
	Fortement exprimé dans
	lumbar spinal ganglion; ; granulocyte; ; urètre; ; strie vasculaire; ; tubercule génital; ; embryon; ; primitive endoderm; ; glande pinéale; ; paroi abdominale; ; lobe pulmonaire droit;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; identical protein binding; chemoattractant activity; protein heterodimerization activity; growth factor activity; serine-type endopeptidase activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Composant cellulaire	membrane; région extracellulaire; platelet alpha granule lumen; milieu extracellulaire;
Processus biologique	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of neuron projection regeneration; positive regulation of interleukin-10 production; positive regulation of cell migration; cellular response to hepatocyte growth factor stimulus; negative regulation of release of cytochrome c from mitochondria; negative regulation of interleukin-6 production; platelet degranulation; negative regulation of apoptotic process; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; positive regulation of angiogenesis; positive regulation of myelination; positive regulation of osteoblast differentiation; myoblast proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; animal organ regeneration; cell morphogenesis; positive regulation of cell population proliferation; hyaluronan metabolic process; positive regulation of DNA biosynthetic process; negative regulation of peptidyl-serine phosphorylation; Transition épithélio-mésenchymateuse; positive regulation of peptidyl-tyrosine phosphorylation; cell chemotaxis; liver development; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of p38MAPK cascade; prolifération cellulaire; negative regulation of autophagy; hepatocyte growth factor receptor signaling pathway; negative regulation of inflammatory response; positive regulation of transcription by RNA polymerase II; regulation of tau-protein kinase activity; protéolyse; positive chemotaxis; MAPK cascade; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphate biosynthetic process; mitose; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; cytokine-mediated signaling pathway; epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologues
	3082
	15234
	ENSG00000019991
	ENSMUSG00000028864
	P14210
	Q08048
	NM_000601; NM_001010931; NM_001010932; NM_001010933; NM_001010934
	NM_010427; NM_001289458; NM_001289459; NM_001289460; NM_001289461
	NP_000592; NP_001010931; NP_001010932; NP_001010933; NP_001010934
	NP_001276387; NP_001276388; NP_001276389; NP_001276390; NP_034557
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le facteur de croissance des hépatocytes (Hepatocyte growth factor, HGF) est un facteur de croissance, agent mitogène des hépatocytes (cellules du foie). Il se lie au récepteur tyrosine kinase c-met (MET)^[5]. Son gène est le HGF situé sur le chromosome 7 humain^[5].

Inhibiteurs

Ficlatuzumab

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000019991 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000028864 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ ^{a et b} (en) George K. Michalopoulos et Reza Zarnegar, « Hepatocyte growth factor », Hepatology, vol. 15, n^o 1,‎ janvier 1992, p. 149–155 (DOI 10.1002/hep.1840150125, lire en ligne, consulté le 3 janvier 2024)

Bibliographie

Michalopoulos GK, Zarnegar R, « Hepatocyte Growth Factor », Hepatology, vol. 15, n^o 1,‎ 1992, p. 149–54 (DOI 10.1002/hep.1840150125)
Nakamura T, « Structure and function of hepatocyte growth factor », Prog. Growth Factor Res., vol. 3, n^o 1,‎ 1992, p. 67–85 (PMID 1838014, DOI 10.1016/0955-2235(91)90014-U)
Ware LB, Matthay MA, « Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair », Am. J. Physiol. Lung Cell Mol. Physiol., vol. 282, n^o 5,‎ 2002, L924–40 (PMID 11943656, DOI 10.1152/ajplung.00439.2001)
Funakoshi H, Nakamura T, « Hepatocyte growth factor: from diagnosis to clinical applications », Clin. Chim. Acta, vol. 327, n^os 1–2,‎ 2003, p. 1–23 (PMID 12482615, DOI 10.1016/S0009-8981(02)00302-9)
Skibinski G, « The role of hepatocyte growth factor/c-met interactions in the immune system », Arch. Immunol. Ther. Exp. (Warsz.), vol. 51, n^o 5,‎ 2004, p. 277–82 (PMID 14626426)
Kalluri R, Neilson EG, « Epithelial-mesenchymal transition and its implications for fibrosis », J. Clin. Invest., vol. 112, n^o 12,‎ 2004, p. 1776–84 (PMID 14679171, PMCID 297008, DOI 10.1172/JCI20530)
Hurle RA, Davies G, Parr C, MD Mason, SA Jenkins, HG Kynaston et WG Jiang, « Hepatocyte growth factor/scatter factor and prostate cancer: a review », Histol. Histopathol., vol. 20, n^o 4,‎ 2006, p. 1339–49 (PMID 16136515)
Kemp LE, Mulloy B, Gherardi E, « Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors », Biochem. Soc. Trans., vol. 34, n^o Pt 3,‎ 2006, p. 414–7 (PMID 16709175, DOI 10.1042/BST0340414)