Erlotinib

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Identification
Erlotinib

Nom UICPA	N-(3-éthynylphényl)-6,7-di(2-méthoxyéthoxy)quinazolin-4-amine
N^o CAS	183321-74-6
N^o ECHA	100.216.020
SMILES	n1cnc(c2cc(c(cc12)OCCOC)OCCOC)Nc1cc(ccc1)C#C PubChem, vue 3D
InChI	InChI : vue 3D InChI=1/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) InChIKey : AAKJLRGGTJKAMG-UHFFFAOYAM Std. InChI : vue 3D InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) Std. InChIKey : AAKJLRGGTJKAMG-UHFFFAOYSA-N
Propriétés chimiques
Formule	C₂₂H₂₃N₃O₄ [Isomères]
Masse molaire^[1]	393,435 7 ± 0,021 g/mol C 67,16 %, H 5,89 %, N 10,68 %, O 16,27 %,

Unités du SI et CNTP, sauf indication contraire.
modifier

L'erlotinib est un anticancéreux, utilisé dans certains cancers comme le CBNPC (Cancer Bronchique Non à Petites Cellules) ou encore le cancer du pancréas.

Mode d'action

L'erlotinib inhibe l'EGFR, une tyrosine kinase, empêchant son activation par auto-phosphorylation, empêchant la transduction de signaux bénéfiques à la cancérogenèse. En raison du blocage en aval de la signalisation, la prolifération des cellules est arrêtée, et la mort cellulaire est induite par la voie intrinsèque de l'apoptose.

Notes et références

↑ Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.

Voir aussi

: document utilisé comme source pour la rédaction de cet article.

Bibliographie

(en) J. Dowell, J. Minna et P. Kirkpatrick, « Erlotinib hydrochloride », Nat Rev Drug Discov, n^o 4,‎ 2005, p. 13–14 (DOI 10.1038/nrd1612)

Lien externe

« Substance active Erlotinib », avril 2023 (consulté le 10 mai 2023)

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