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Epsine

Epsine 1, Structures protéiques

Les epsines sont des protéines membranaires intervenant dans les processus d'endocytose.

Rôles

Elles intervient, en association avec la clathrine, dans les processus d'endocytose[1].

En médecine

Leur expression est augmentée dans les cancers, favorisant le caractère invasif de ces derniers[2] par l'intermédiaire de l'internalisation de plusieurs récepteurs, dont celui des facteurs de croissance de l’endothélium vasculaire ou ceux de la voie de signalisation Notch[3].

Notes et références

  1. ↑ Chen H, Fre S, Slepnevet VI et al. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis, Nature, 1998;394:793–797
  2. ↑ Coon BG, Direnzo DM, Konieczny SF, Aguilar RC, Epsins’ novel role in cancer cell invasion, Commun Integr Biol, 2011;4:95–97
  3. ↑ Tessneer KL, Cai X, Pasula S et al. Epsin family of endocytic adaptor proteins as oncogenic regulators of cancer progression, J Can Res Updates, 2013;2:144–150

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