Sennosidi

Sennosidi
Sennosidi
Sennosidi
Systemaattinen (IUPAC) nimi
?
Tunnisteet
CAS-numero 8013-11-4
ATC-koodi A06AB06
PubChem CID ?
Kemialliset tiedot
Kaava ?
Moolimassa ?
Farmakokineettiset tiedot
Hyötyosuus ?
Metabolia ?
Puoliintumisaika ?
Ekskreetio ?
Terapeuttiset näkökohdat
Raskauskategoria

C (USA)

Reseptiluokitus


Antotapa Oraalinen, Rektaalinen

Sennosidi tai senna glykosidi on sennakasveista eristetty ulostuslääke. Sitä käytetään joko oraalisesti tai peräsuolen kautta. Suun kautta otettuna vaikutus alkaa 6–12 tunnin kuluessa, peräsuolen kautta lähes välittömästi. Se ei ole yhtä tehokas laksatiivi kuin risiiniöljy. Sennaa on käytetty lääkekasvina jo useita satoja vuosia. [1][2]

Kemiallisesti se on glykosidi.

Sennosidi on WHO:n listalla yhteiskunnalle tärkeimmistä lääkkeistä[3]

Eri sennosideja
Yhdiste Kemiallinen kaava CAS-numero
Sennosidi A C42H38O20 81-27-6
Sennosidi B C42H38O20 128-57-4
Sennosidi C C42H40O19 37271-16-2
Sennosidi D C42H40O19 37271-17-3
Sennosidi E C44H38O23 11137-63-6
Sennosidi F C44H38O23 52842-23-6

Tuotanto Suomessa

Japanilainen silmälääkevalmistaja Santen Pharmaceutical valmisti Tampereella muun muassa sennosidi lääkeraaka-ainetta. Tuotanto päätettiin vuonna 2013 siirtää vuoden 2016 loppuun mennessä Intiaan ja Kiinaan.[4]

Lähteet

  1. Drugs.com: artikkeli sennasta Viitattu 1.1.2016.
  2. Tohtori.fi: Sennosidi Viitattu 1.1.2016.
  3. WHO Model List of Essential Medicines (pdf) lokakuu 2013. World Health Organization. Viitattu 31.12.2015. (englanniksi)
  4. Santenin Tampereen tuotannon alasajo alkamassa, Yle Uutiset 14.1.2014. Viitattu 1.1.2016.

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