WNT3
پروتئین پروتو-آنکوژن Wnt-3 (انگلیسی: Proto-oncogene protein Wnt-3) که بهاختصار «WNT3» نامیدهمیشود، یک پروتئین است که در انسان توسط ژن «WNT3» کد میشود.[۴][۵]
این پروتئین، نوعی مولکولِ سیگنالدهنده است که در چندین فرایند رشد و نمو، ازجمله در تعیین سرنوشت سلولها و شکلدهی به آنها در جریانِ تکامل جنین نقش دارد.
پژوهشها نشان میدهد که ژن تولید کنندهٔ این پروتئین احتمالاً در بروز سرطان پستان، سرطان ریه، سرطان راستروده و سرطان معده هم مؤثر باشد.
این ژن بههمراه ژن دیگری به نام «WNT15»، بر روی بازوی بلند کروموزوم ۱۷ واقع شدهاست.[۵]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000125 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
- ↑ ۵٫۰ ۵٫۱ "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".
- مشارکتکنندگان ویکیپدیا. «WNT3». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۸ دسامبر ۲۰۱۷.
بیشتر بخوانید
- Nusse R; Brown A; Papkoff J; et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family". Cell. 64 (2): 231. doi:10.1016/0092-8674(91)90633-A. PMID 1846319.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
- Liu P; Wakamiya M; Shea MJ; et al. (1999). "Requirement for Wnt3 in vertebrate axis formation". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID 10431240.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Gazit A; Yaniv A; Bafico A; et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Katoh M (2002). "Molecular cloning and characterization of human WNT3". Int. J. Oncol. 19 (5): 977–82. doi:10.3892/ijo.19.5.977. PMID 11604997.
- Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Niemann S; Zhao C; Pascu F; et al. (2004). "Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMC 1182269. PMID 14872406.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Chiba H; Kobune M; Kato J; et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells". Exp. Hematol. 32 (12): 1194–203. doi:10.1016/j.exphem.2004.08.010. PMID 15588944.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.
 | این یک مقالهٔ خرد زیستشناسی مولکولی است. میتوانید با گسترش آن به ویکیپدیا کمک کنید. |
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