PRDX5
پروکسیردوکسین ۵ (انگلیسی: Peroxiredoxin-5) یک پروتئین است که در انسان توط ژن «PRDX5» کدگذاری میشود. این ژن بر روی کروموزوم ۱۱ واقع شدهاست.[۴] این پروتئین یکی از ۶ عضو خانوادهٔ آنزیمهای آنتیاکسیدان پروکسیردوکسین است.
پروکسیردوکسین ۵ در سطح گستردهای در بدن وجود دارد و جایگاه آن در میتوکندری، پراکسیزوم، سیتوزول و هسته یاخته است.[۵]
اهمیت بالینی
کُنز و همکاران با بررسی ۹۸ بیمار مبتلا به سکته مغزی نشان دادند که سطح پروکسیردوکسین ۵ بهطور معکوس با پیشرفت سکته مغزی مربوط است و بدین ترتیب، شاید بتوان از پروکسیردوکسین ۵ به عنوان یک نشانگر زیستی جهت التهاب در سکتههای حاد مغزی استفاده نمود.[۶]
در سرطان پستان انسان، از بین رفتن فاکتور رونویسی GATA1 منجر به افزایش بیان پروکسیردوکسین ۵ و مهار آپوپتوز میگردد.[۷] همچنین افزایش قابلتوجه پروکسیردوکسین ۵ در آستروسیتهای موجود در ضایعات مغزی-عصبی در بیماری اماس دیده میشود.[۸] احتمال میرود ژن PRDX5 در بروز سارکوئیدوز هم دخیل باشد.[۹]
منابع
- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000024953 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "PRDX5 peroxiredoxin 5 [Homo sapiens (human)]". NCBI. Retrieved 2016-07-19.
- ↑ Knoops B, Goemaere J, Van der Eecken V, Declercq JP (August 2011). "Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin". Antioxidants & Redox Signaling. 15 (3): 817–29. doi:10.1089/ars.2010.3584. PMID 20977338.
- ↑ Kunze A, Zierath D, Tanzi P, Cain K, Becker K (February 2014). "Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke". Stroke. 45 (2): 608–10. doi:10.1161/STROKEAHA.113.003813. PMC 3946812. PMID 24385276.
- ↑ Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (July 2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". The Journal of Biological Chemistry. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.
- ↑ Holley JE, Newcombe J, Winyard PG, Gutowski NJ (September 2007). "Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes". Multiple Sclerosis. 13 (8): 955–61. doi:10.1177/1352458507078064. PMID 17623739.
- ↑ Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S (November 2012). "A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1". American Journal of Respiratory and Critical Care Medicine. 186 (9): 877–85. doi:10.1164/rccm.201204-0708OC. PMID 22837380.
- مشارکتکنندگان ویکیپدیا. «PRDX5». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۶ آوریل ۲۰۱۸.
برای مطالعهٔ بیشتر
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- Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (July 2000). "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate". The Journal of Biological Chemistry. 275 (27): 20346–54. doi:10.1074/jbc.M001943200. PMID 10751410.
- Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. JSTOR 123500. PMC 16901. PMID 10931946.
- Declercq JP, Evrard C, Clippe A, Stricht DV, Bernard A, Knoops B (August 2001). "Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution". Journal of Molecular Biology. 311 (4): 751–9. doi:10.1006/jmbi.2001.4853. PMID 11518528.
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- Wang MX, Wei A, Yuan J, Trickett A, Knoops B, Murrell GA (November 2002). "Expression and regulation of peroxiredoxin 5 in human osteoarthritis". FEBS Letters. 531 (2): 359–62. doi:10.1016/S0014-5793(02)03511-1. PMID 12417342.
- Leyens G, Donnay I, Knoops B (December 2003). "Cloning of bovine peroxiredoxins-gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 136 (4): 943–55. doi:10.1016/S1096-4959(03)00290-2. PMID 14662316.
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