PCK1

PCK1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
معین‌کننده‌ها
نام‌های دیگر	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
شناسه‌های بیرونی	OMIM: 614168 MGI: 97501 HomoloGene: 1944 GeneCards: PCK1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	173,001,066 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • manganese ion binding; • GDP binding; • phosphoenolpyruvate carboxykinase activity; • GTP binding; • metal ion binding; • carboxylic acid binding; • purine nucleotide binding; • lyase activity; • carboxy-lyase activity; • magnesium ion binding; • phosphoenolpyruvate carboxykinase (GTP) activity;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • اگزوزوم;
فرایند زیستی	• glucose homeostasis; • internal protein amino acid acetylation; • سوخت‌وساز لیپید; • response to activity; • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH; • oxaloacetate metabolic process; • response to insulin; • glyceroneogenesis; • cellular response to potassium ion starvation; • cellular response to retinoic acid; • response to lipid; • cellular response to hypoxia; • cellular response to fructose stimulus; • response to interleukin-6; • glucose metabolic process; • GO:0010260 پیرش; • response to methionine; • cellular response to interleukin-1; • cellular response to glucagon stimulus; • cellular response to cAMP; • cellular response to insulin stimulus; • cellular response to tumor necrosis factor; • response to lipopolysaccharide; • نوگلوکززایی;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5105
	18534
	ENSG00000124253
	ENSMUSG00000027513
	P35558
	Q9Z2V4
	XM_024451888 NM_002591، XM_024451888
	NM_011044
	XP_024307656 NP_002582، XP_024307656
	NP_035174
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فسفوئنول‌پیرووات کربوکسی‌کیناز ۱ (محلول) (انگلیسی: Phosphoenolpyruvate carboxykinase 1 - soluble) یک آنزیم است که در انسان توسط ژن «PCK1» کدگذاری می‌شود.^[۴]^[۵]

این آنزیم یکی از نقاط کنترلی اصلی در تنظیم فرایند نوگلوکززایی است و به‌همراه گوانوزین تری‌فسفات، ساخت اسید فسفوئنول‌پیروویک را از اگزالواستیک اسید سبب می‌شود.

بیان این ژن توسط ترشح انسولین، گلوکوکورتیکوئید، گلوکاگون و آدنوزین مونوفسفات حلقه‌ای و رژیم غذایی، تنظیم می‌گردد.

جستارهای وابسته

فسفوئنول‌پیرووات کربوکسی‌کیناز

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027513 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)".
↑ Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743.

مشارکت‌کنندگان ویکی‌پدیا. «PCK1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ اکتبر ۲۰۱۸.

بیشتر بخوانید

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Pilz AJ, Willer E, Povey S, Abbott CM (1993). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743.
Giralt M, Park EA, Gurney AL, et al. (1991). "Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements". J. Biol. Chem. 266 (32): 21991–6. PMID 1657985.
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Yu H, Thun R, Chandrasekharappa S, et al. (1993). "Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2". Genomics. 15 (1): 219–21. doi:10.1006/geno.1993.1040. PMID 8432541.
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Jurado LA, Song S, Roesler WJ, Park EA (2002). "Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression". J. Biol. Chem. 277 (31): 27606–12. doi:10.1074/jbc.M201429200. PMID 11997389.
Wilson HL, McFie PJ, Roesler WJ (2003). "Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter". J. Biol. Chem. 277 (46): 43895–902. doi:10.1074/jbc.M203169200. PMID 12237288.
Borgius LJ, Steffensen KR, Gustafsson JA, Treuter E (2003). "Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP". J. Biol. Chem. 277 (51): 49761–6. doi:10.1074/jbc.M205641200. PMID 12324453.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chakravarty K, Wu SY, Chiang CM, et al. (2004). "SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver". J. Biol. Chem. 279 (15): 15385–95. doi:10.1074/jbc.M309905200. PMID 14744869.
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