پروتئین یکپارچهٔ پوستهای NKG2-F نوع ۲ (انگلیسی: NKG2-F type II integral membrane protein) یک پروتئین است که در انسان توسط ژن «KLRC4» کُدگذاری میشود.[۲][۳]
سلولهای کشنده طبیعی، لنفوسیتهایی هستند که در تجزیه و کشتار برخی انواع سلولهای توموری یا آلودهشده به ویروس نقش دارند و نیازی به فعالشدگی قبلی هم ندارند. این سلولها در تنظیم ایمنی سلولی و ایمنی هومورال هم دخالت دارند.
منابع
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑Plougastel B, Trowsdale J (Aug 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID9598306.
Vivier E, Tomasello E, Paul P (2002). "Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?". Curr. Opin. Immunol. 14 (3): 306–11. doi:10.1016/S0952-7915(02)00337-0. PMID11973127.
Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes". Eur. J. Immunol. 27 (11): 2835–9. doi:10.1002/eji.1830271114. PMID9394807.
Glienke J, Sobanov Y, Brostjan C, et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics. 48 (3): 163–73. doi:10.1007/s002510050420. PMID9683661.
Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA". Nat. Immunol. 2 (5): 443–51. doi:10.1038/87757. PMID11323699.
O'Callaghan CA, Cerwenka A, Willcox BE, et al. (2001). "Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60". Immunity. 15 (2): 201–11. doi:10.1016/S1074-7613(01)00187-X. PMID11520456.
Girardi M, Oppenheim DE, Steele CR, et al. (2001). "Regulation of cutaneous malignancy by gammadelta T cells". Science. 294 (5542): 605–9. doi:10.1126/science.1063916. PMID11567106.
Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3". Immunity. 15 (6): 1039–49. doi:10.1016/S1074-7613(01)00241-2. PMID11754823.
Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID12426565.
McFarland BJ, Kortemme T, Yu SF, et al. (2004). "Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands". Structure. 11 (4): 411–22. doi:10.1016/S0969-2126(03)00047-9. PMID12679019.
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
