پروتئین یکپارچهٔ پوستهای NKG2-C نوع ۲ (انگلیسی: NKG2-C type II integral membrane protein) که با نامهای CD159c و NKG2C هم شناخته میشود، یک پروتئین است که در انسان توسط ژن «KLRC2» کُدگذاری میشود.[۲][۳]
سلولهای کشنده طبیعی، لنفوسیتهایی هستند که در تجزیه و کشتار برخی انواع سلولهای توموری یا آلودهشده به ویروس نقش دارند و نیازی به فعالشدگی قبلی هم ندارند. این سلولها در تنظیم ایمنی سلولی و ایمنی هومورال هم دخالت دارند.
↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑Plougastel B, Trowsdale J (Apr 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID9598306.
↑Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. PMID8943374.
↑Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID10320637.
Lanier LL, Corliss B, Wu J, Phillips JH (Jun 1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity. 8 (6): 693–701. doi:10.1016/S1074-7613(00)80574-9. PMID9655483.
Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F (Aug 1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics. 48 (3): 163–73. doi:10.1007/s002510050420. PMID9683661.
Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID10320637.
Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P (Jun 2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans". Immunity. 12 (6): 687–98. doi:10.1016/S1074-7613(00)80219-8. PMID10894168.
Hikami K, Tsuchiya N, Yabe T, Tokunaga K (Mar 2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population". Genes and Immunity. 4 (2): 160–7. doi:10.1038/sj.gene.6363940. PMID12618865.
Miyashita R, Tsuchiya N, Hikami K, Kuroki K, Fukazawa T, Bijl M, Kallenberg CG, Hashimoto H, Yabe T, Tokunaga K (Jan 2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion". International Immunology. 16 (1): 163–8. doi:10.1093/intimm/dxh013. PMID14688071.
Gumá M, Busch LK, Salazar-Fontana LI, Bellosillo B, Morte C, García P, López-Botet M (Jul 2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells". European Journal of Immunology. 35 (7): 2071–80. doi:10.1002/eji.200425843. PMID15940674.
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