مجموعه تمایزی ۶۹ (انگلیسی: Cluster of Differentiation ۶۹) یک پروتئین تراپوستهای از نوع لکتین نوع سی است که در انسان توسط ژن «CD69» کُدگذاری میشود.
این پروتئین، یکی از نخستین نشانگرهای فعال سازی است که بر روی سطح سلولهای خونساز اولیه، لنفوسیتهای تی و بسیاری دیگر از انواع سلولهای سیستم ایمنی بدن ظاهر میشود.[۴] این مولکول همچنین در تمایز لنفوسیتهای تی و نگهداشتن آنان در درون احشاء لنفاوی نقش دارد.
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Santis AG, López-Cabrera M, Hamann J, Strauss M, Sánchez-Madrid F (July 1994). "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors". European Journal of Immunology. 24 (7): 1692–7. doi:10.1002/eji.1830240735. PMID8026529.
Ziegler SF, Ramsdell F, Hjerrild KA, Armitage RJ, Grabstein KH, Hennen KB, Farrah T, Fanslow WC, Shevach EM, Alderson MR (July 1993). "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens". European Journal of Immunology. 23 (7): 1643–8. doi:10.1002/eji.1830230737. PMID8100776.
Vance BA, Bennett MJ, Ward Y, Gress RG, Kearse KP (August 1999). "Distinct but dispensable N-glycosylation of human CD69 proteins". Archives of Biochemistry and Biophysics. 368 (2): 214–20. doi:10.1006/abbi.1999.1322. PMID10441371.
Blázquez MV, Macho A, Ortiz C, Lucena C, López-Cabrera M, Sánchez-Madrid F, Muñoz E (September 1999). "Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins". AIDS Research and Human Retroviruses. 15 (13): 1209–18. doi:10.1089/088922299310304. PMID10480634.
Liu CC, Huang KJ, Lin YS, Yeh TM, Liu HS, Lei HY (October 2002). "Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection". Journal of Medical Virology. 68 (2): 241–52. doi:10.1002/jmv.10198. PMID12210415.
Foerster M, Haefner D, Kroegel C (October 2002). "Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling". Scandinavian Journal of Immunology. 56 (4): 417–28. doi:10.1046/j.1365-3083.2002.01111.x. PMID12234263.
Weigel G, Griesmacher A, Karimi A, Zuckermann AO, Grimm M, Mueller MM (October 2002). "Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients". The Journal of Heart and Lung Transplantation. 21 (10): 1074–9. doi:10.1016/S1053-2498(02)00440-0. PMID12398872.
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