Propofol
| Propofol | |
|---|---|
 | |
| Formula kimikoa | C12H18O |
| SMILES kanonikoa | 2D eredua |
| MolView | 3D eredua |
| Mota | konposatu kimiko |
| Ezaugarriak | |
| Dentsitatea | 0,955 g/cm³ (20 ℃, likido) |
| Errefrakzio indiziea | 1,514 (20 ℃, 589 nm) |
| Fusio-puntua | 18 ℃ |
| Irakite-puntua | 247 ℃ (101,325 kPa) |
| Masa molekularra | 178,136 Da |
| Erabilera | |
| Konposatu aktiboa | Diprivan (en)  |
| Tratatzen du | min, agitation in dementia (en) , status epilepticus (en) , subacute delirium (en) eta Anestesia |
| Elkarrekintza | Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (en) |
| Haurdunaldia | Australian pregnancy category C (en) eta US pregnancy category B (en) |
| Rola | GABAA receptor positive allosteric modulators (en) , hypnotics and sedatives (en) , intravenous anesthetics (en) eta WHO farmako esentzial |
| Identifikatzaileak | |
| InChlKey | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
| CAS zenbakia | 2078-54-8 |
| ChemSpider | 4774 |
| PubChem | 4943 |
| Reaxys | 1866484 |
| Gmelin | 44915 |
| ChEMBL | CHEMBL526 |
| EC zenbakia | 218-206-6 |
| ECHA | 100.016.551 |
| MeSH | D015742 |
| RxNorm | 8782 |
| Human Metabolome Database | HMDB0014956 |
| UNII | YI7VU623SF |
| NDF-RT | N0000147620 |
| KEGG | D00549 |
| PDB Ligand | PFL |
Propofol [1] anestesia orokorraren indukzio eta mantentzerako erabiltzen den zain barneko farmako baten osagai aktiboa da. Propofola lehen Diprivan marka-izenarekin onartu zen bainan ordutik bertsio generiko asko kaleratu dira. Zain barneko administrazioa erabiltzen da konortea galtzea eragiteko, eta ondoren anestesia mantendu daiteke hainbat famako-konbinazio erabiliz. Propofola soja-olioa eta lezitina erabiliz injekta daitekeen emultsio esteril baten barruan fabrikatzen da, eta horrek kolore zuri-esnetsua ematen dio.[2]
Erreferentziak
- ↑ «Propofol» PubChem (U.S. National Library of Medicine).
- ↑ «Making Stable, Sterile Propofol» www.microfluidics-mpt.com.
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