Receptor de TGF-beta 1

Receptor del factor de crecimiento transformante beta 1

Estructura tridimensional del receptor de TGF-beta 1.
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
1b6c
Identificadores
Símbolos TGFBR1 (HGNC: 11772) ACVRLK4, AAT5, ALK-5, ALK5, SKR4, TGFR-1
Identificadores
externos
Locus Cr. 9 q22.33
Ortólogos
Especies
Humano Ratón
Entrez
7046
UniProt
P36897 n/a
RefSeq
(ARNm)
NP_004603 n/a
[editar datos en Wikidata]

El receptor del factor de crecimiento transformante beta 1 (TGFBR1) es un receptor de TGF-beta codificado en humanos por el gen HGNC TGFBR1 , corresponde a la actividad enzimática EC 2.7.11.30

Este receptor de TGF-beta 1 forma un complejo heterodimérico con el receptor de TGF-beta 2 cuando se encuentra unido al TGF-beta, transduciendo la señal desde la superficie celular al citoplasma. Este receptor posee actividad serina/treonina proteína cinasa. Se han asociado mutaciones de este gen con el síndrome de Loeys-Dietz (LDAS).[1]​

Interacciones

El receptor de TGF-beta 1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

  1. ↑ «Entrez Gene: TGFBR1 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)». 
  2. ↑ Mochizuki, Toshiaki; Miyazaki Hideyo, Hara Takane, Furuya Toshio, Imamura Takeshi, Watabe Tetsuro, Miyazono Kohei (Jul. de 2004). «Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling». J. Biol. Chem. (United States) 279 (30): 31568-74. ISSN 0021-9258. PMID 15148321. doi:10.1074/jbc.M313977200. 
  3. ↑ Asano, Yoshihide; Ihn Hironobu, Yamane Kenichi, Kubo Masahide, Tamaki Kunihiko (Jan. de 2004). «Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts». J. Clin. Invest. (United States) 113 (2): 253-64. ISSN 0021-9738. PMID 14722617. doi:10.1172/JCI16269. 
  4. ↑ Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec. de 2003). «Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7». EMBO J. (England) 22 (24): 6458-70. ISSN 0261-4189. PMID 14657019. doi:10.1093/emboj/cdg632. 
  5. ↑ Kavsak, P; Rasmussen R K, Causing C G, Bonni S, Zhu H, Thomsen G H, Wrana J L (Dec. de 2000). «Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation». Mol. Cell (United States) 6 (6): 1365-75. ISSN 1097-2765. PMID 11163210. 
  6. ↑ Hayashi, H; Abdollah S, Qiu Y, Cai J, Xu Y Y, Grinnell B W, Richardson M A, Topper J N, Gimbrone M A, Wrana J L, Falb D (Jun. de 1997). «The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling». Cell (UNITED STATES) 89 (7): 1165-73. ISSN 0092-8674. PMID 9215638. 
  7. ↑ a b Datta, P K; Moses H L (mayo. de 2000). «STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling». Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157-67. ISSN 0270-7306. PMID 10757800. 
  8. ↑ Wang, T; Donahoe P K, Zervos A S (Jul. de 1994). «Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12». Science (UNITED STATES) 265 (5172): 674-6. ISSN 0036-8075. PMID 7518616. 
  9. ↑ Liu, F; Ventura F, Doody J, Massagué J (Jul. de 1995). «Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs». Mol. Cell. Biol. (UNITED STATES) 15 (7): 3479-86. ISSN 0270-7306. PMID 7791754. 
  10. ↑ Ebner, R; Chen R H, Lawler S, Zioncheck T, Derynck R (Nov. de 1993). «Determination of type I receptor specificity by the type II receptors for TGF-beta or activin». Science (UNITED STATES) 262 (5135): 900-2. ISSN 0036-8075. PMID 8235612. 
  11. ↑ Oh, S P; Seki T, Goss K A, Imamura T, Yi Y, Donahoe P K, Li L, Miyazono K, ten Dijke P, Kim S, Li E (Mar. de 2000). «Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2626-31. ISSN 0027-8424. PMID 10716993. 
  12. ↑ a b Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. de 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9): 6727-38. ISSN 0021-9258. PMID 11102446. doi:10.1074/jbc.M008340200. 
  13. ↑ Kawabata, M; Imamura T, Miyazono K, Engel M E, Moses H L (Dec. de 1995). «Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha». J. Biol. Chem. (UNITED STATES) 270 (50): 29628-31. ISSN 0021-9258. PMID 8530343. 
  14. ↑ Griswold-Prenner, I; Kamibayashi C, Maruoka E M, Mumby M C, Derynck R (Nov. de 1998). «Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A». Mol. Cell. Biol. (UNITED STATES) 18 (11): 6595-604. ISSN 0270-7306. PMID 9774674. 
  15. ↑ Kawabata, M; Chytil A, Moses H L (Mar. de 1995). «Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor». J. Biol. Chem. (UNITED STATES) 270 (10): 5625-30. ISSN 0021-9258. PMID 7890683. 
  16. ↑ Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. de 2002). «Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II». J. Biol. Chem. (United States) 277 (32): 29197-209. ISSN 0021-9258. PMID 12015308. doi:10.1074/jbc.M111991200. 
  17. ↑ Barbara, N P; Wrana J L, Letarte M (Jan. de 1999). «Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily». J. Biol. Chem. (UNITED STATES) 274 (2): 584-94. ISSN 0021-9258. PMID 9872992. 
  18. ↑ Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. de 2008). «Critical regulation of TGFbeta signaling by Hsp90». Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27): 9244-9. PMID 18591668. doi:10.1073/pnas.0800163105. 
  19. ↑ Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. de 1998). «Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling». J. Biol. Chem. (UNITED STATES) 273 (52): 34671-4. ISSN 0021-9258. PMID 9856985. 

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