Palonosetron

Palonosetron
Nombre (IUPAC) sistemático
(3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,
4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
Identificadores
Número CAS 135729-61-2
Código ATC A04AA05
PubChem 148211
DrugBank APRD00351
Datos químicos
Fórmula C: 29; H: 24; N: 2; O: 1
Peso mol. 296,407 g/mol
Farmacocinética
Biodisponibilidad 100 % IV
Unión proteica 62 %
Metabolismo hepático
Vida media 40 h
Excreción renal 80% (del cual 49% inalterado)
Datos clínicos
Cat. embarazo B1 (Au), B (U.S.)
Estado legal Uso hospitalario (España), Rx-only (U.S.)
Vías de adm. intravenosa
[editar datos en Wikidata]

Palonosetron (DCI), nombre comercial Aloxi, es un fármaco que pertenece al grupo de los antagonistas de los receptores de la 5-HT3, genéricamente conocidos como setrones, que está indicado en la prevención y tratamiento de las náuseas y vómitos inducidos por la quimioterapia (NVIQ). Palonosetron es el setrón más efectivo en el control de los NVIQ diferidos, o sea, aquellos que aparecen más allá de las 24 horas tras la administración de la primera dosis de un ciclo de quimioterapia. De hecho, es el único setrón aprobado por la agencia americana FDA (Food and Drug Administration) específicamente en NVIQ diferidos.[1]​

Palonosetron se administra endovenosamente, en una única dosis, 30 minutos antes de recibir la quimioterapia.[1]​

Palonosetron es el último setrón que se ha incorporado a la práctica clínica.


Referencias

  1. ↑ a b De Leon. Palonosetron (Aloxi): a second-generation 5-HT(3) receptor antagonist for chemotherapy-induced nausea and vomiting. Proceedings (Baylor University. Medical Center) 19 (4): 413–6 (PMID=17106506). Texto completo: PMC1618755.


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